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High-expansibility medical polysaccharide-based material and application thereof

A high-expansion, polysaccharide technology, applied in medical science, bandages, prostheses, etc., to achieve the effect of good liquid absorption and expansion performance

Active Publication Date: 2013-03-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

High expansibility polysaccharide medical materials have not been reported yet

Method used

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  • High-expansibility medical polysaccharide-based material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Preparation of granular high-swellability cross-linked sodium hyaluronate polysaccharide medical material:

[0011] Weigh 1.0g of sodium hyaluronate powdery solid, put it in a 500mL clean beaker, add 99mL of distilled water, stir and dissolve at room temperature to obtain a sodium hyaluronate solution with a weight percentage (the same below) of 1.0%, and stir down to the solution Add 0.05 mol / L aqueous hydrochloric acid dropwise to adjust the pH value of the solution to 4.5. Add dropwise a 2% carbodiimide solution of a cross-linking agent to the hyaluronic acid solution under stirring, the amount of the cross-linking agent being added dropwise is such that the molar ratio of the hyaluronic acid to the cross-linking agent is 20:1, continue stirring for 48 hours, and the solution The sodium hyaluronate in the gel is cross-linked to form a gel. Add 350mL of 95% ethanol aqueous solution into the beaker, stir to obtain a precipitate, Buchner funnel suction filtra...

Embodiment 2

[0012] Example 2 Preparation of granular high-swellability cross-linked sodium hyaluronate composite polysaccharide medical material 1:

[0013] Weigh 0.5 g of sodium hyaluronate powdery solid and 0.5 g of konjac gel, place in a 500 mL clean beaker, add 99 mL of distilled water, stir and dissolve at room temperature, and obtain a complex polysaccharide solution of 1.0% by weight (the same below), 0.05 mol / L hydrochloric acid aqueous solution was added dropwise to the complex polysaccharide solution under stirring to adjust the pH value of the solution to 4.5. Add dropwise a 2% carbodiimide solution of a cross-linking agent to the complex polysaccharide solution under stirring, the amount of the cross-linking agent being added dropwise is that the molar ratio of hyaluronic acid to the cross-linking agent is 15:1, and continue to stir for 48 hours. The polysaccharides are cross-linked to form a gel. Add 350mL of 95% ethanol aqueous solution into the beaker, stir to obtain a pre...

Embodiment 3

[0014] Embodiment 3 Preparation of granular high-swellability cross-linked sodium hyaluronate composite polysaccharide medical material 2:

[0015] Weigh 0.5g of sodium hyaluronate powdery solid and 0.5g of pachyphyllan, put them in a 500mL clean beaker, add 99mL of distilled water, stir and dissolve at room temperature, and obtain a complex polysaccharide solution with a weight percentage (the same below) of 1.0%, stir Add dropwise 0.05 mol / L hydrochloric acid aqueous solution to the complex polysaccharide solution to adjust the pH value of the solution to 4.5. Add dropwise a 2% carbodiimide solution of a cross-linking agent to the complex polysaccharide solution under stirring, the amount of the cross-linking agent being added dropwise is that the molar ratio of hyaluronic acid to the cross-linking agent is 15:1, and continue to stir for 48 hours. The polysaccharides are cross-linked to form a gel. Add 350mL of 95% ethanol aqueous solution into the beaker, stir to obtain a ...

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Abstract

The invention relates to a medical material, and in particular relates to a high-expansibility medical polysaccharide-based material and an application thereof. The hyaluronic preparation in the prior art is nontoxic, brings no inflammatory reaction and immunoreaction to a human body, and is higher in biosecurity, but the raw materials are higher in cost. The powdered or granular high-expansibility medical supramolecular polysaccharide-based material provided by the invention can absorb water to expand in the presence of water, can absorb a large amount of water and blood, is over thirtyfold in absorption, has high liquid-absorbed expansibility, and can be used as a medical material for absorbing tissue exudate, or used as the medical material for tissue filling, or the medical material for stopping bleeding.

Description

technical field [0001] The invention relates to a medical material, in particular to a high-swellability polysaccharide medical material and its application. Background technique [0002] Soft tissue filling materials are widely used in clinical plastic surgery. These filling materials include biological filling materials and synthetic non-biological filling materials. Among them, biological soft tissue filling materials have better safety and tissue compatibility and are more ideal. soft tissue filling materials. Biological soft tissue filling materials mainly include cross-linked hyaluronic acid and its derivatives, as well as collagen. Domestic hyaluronic acid preparations have a wide range of clinical applications, such as cataract extraction, intraocular lens implantation and other ophthalmic operations as viscoelastic agents, orthopedic injectable bone joints for the treatment of osteoarthritis. Hyaluronic acid preparations such as Hylaform and Restylane approved by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/60A61L27/20A61L31/04
Inventor 韩宝芹刘万顺彭燕飞宋福来杨照
Owner OCEAN UNIV OF CHINA
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