Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A compound amino acid, injection technology, applied in drug combination, metabolic diseases, peptide/protein components, etc., can solve problems such as harm to patients, affecting product qualification rate, unqualified antihypertensive substances, etc.
Inactive Publication Date: 2013-03-27
TIANJIN JINYAO GRP
View PDF5 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Such as antibiotics, traditional Chinese medicine injections, amino acids, polypeptides, etc., compound amino acid injection (15HBC), as an injection containing histidine in the formula, after heat sterilization, its antihypertensive substances are prone to unqualified problems. Affect the qualification rate of the product, and easily cause potential harm to patients, so reducing the content of its antihypertensive substances has become a problem to be solved in the prior art
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0015] In the embodiment, the prescription in the following table is the feed amount calculated by 10000ml, and the subpackage adopts 250ml glass bottle. Sterilization was performed by autoclaving at 105°C for 45 minutes. After adding the pH regulator, adjust the pH to 5.0-5.5 with 0.1M sodium hydroxide solution or hydrochloric acid. (If the pH is qualified, you don’t need to add more)
[0016] Described injection adopts following method to prepare
[0017] 1) Take 15-25% of the prescribed amount of water for injection, put in the prescribed amount of glucose to dissolve, add 0.2% (g / ml) medicinal charcoal, stir and place for 30 minutes, and set aside.
[0018] 2) Take 35% to 45% of the prescribed amount of water for injection, under the protection of nitrogen, heat to 40~60°C, add arginine, tyrosine, isoleucine, valine, proline, leucine Acid, Lysine Acetate, Methionine, Threonine, Alanine, Glutamic Acid, Aspartic Acid, Serine, N-Acetyl-L-Tryptophan, Glycine, Phenylalanine,...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a compound amino acid injection (18AA-IV) composition. Each 1000ml of the compound amino acid injection composition contains 4.0-4.5g of leucine, 1.5-2.0g of isoleucine, 4.0-4.5g of lysine acetate, 1.0-1.5g of methionine, 1.8-2.2g of histidine, 0.10-0.15g of tyrosine, 1.8-2.3g of alanine, 3-4g of glycine, 1.0-1.5g of aspartic acid, 2.0-2.5g of glutamic acid, 1.0-1.5g of proline, 3.0-3.5g of phenylalanine, 2.0-2.5g of threonine, 0.3-0.8g of N-acetyl-L-tyrosine, 1-2g of valine, 0.5-1g of serine, 2-3g of arginine, 0.2-0.7g of cysteine hydrochloride and 70-80g of glucose and is characterized in that each 1000ml of the injection further contains 0.5-1g of lactic acid.
Description
Technical field: [0001] The invention relates to an amino acid-containing injection and a manufacturing method thereof. Background technique: [0002] Amino acids are the basic units that make up proteins. Compound amino acid injection, as a nutritional supplement for intravenous injection, is widely used in nutritional support therapy, such as the existing 18 kinds of amino acid compound injection with the general name of compound amino acid injection (18AA-IV), its formula is to contain bright Amino acid 4.17g, isoleucine 1.87g, lysine acetate 4.13g, methionine 1.17g, histidine 2.00g, tyrosine 0.116g, alanine 2.07g, glycine 3.57g, asparagine Amino acid 1.27g, glutamic acid 2.17g, proline 1.10g, phenylalanine 3.11g, threonine 2.17g, N-acetyl L-tryptophan 0.52g, valine 1.50g, serine 0.73g , arginine 2.63g, cysteine hydrochloride 0.48g, glucose 75g, sodium metabisulfite 1.0g, according to the existing regulations, those from animals and plants, microbial fermentation extr...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more