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Use of chicoric acid and derivatives for regulating skin pigmentation

A technology of abnormal skin pigmentation and cichoric acid, which is applied in skin care preparations, skin diseases, applications, etc., and can solve the problems of irritating side effects and unsatisfactory effects of local active agents

Active Publication Date: 2013-03-06
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the currently available methods of treatment are not entirely satisfactory, especially with regard to the side effects that often accompany them, such as the irritating side effects of some topical active agents

Method used

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  • Use of chicoric acid and derivatives for regulating skin pigmentation
  • Use of chicoric acid and derivatives for regulating skin pigmentation
  • Use of chicoric acid and derivatives for regulating skin pigmentation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Effect of Chichoric Acid and Chicory Extract on Skin Pigmentation

[0076] To assess the potential beneficial effects of ingredients on skin depigmentation or promoting hyperpigmentation, we performed 2 experiments with 2D cultures of murine melanocytes (B16): 1 - assessing melanogenesis and 2 - assessing tyrosinase production.

[0077] 1. cell culture conditions

[0078] Incubate B16 cells in DMEM containing 1 g / L glucose without phenol red supplemented with 10% fetal bovine serum in a humidified culture room at 37 °C with 5% CO 2 cultivated under conditions.

[0079] 2. Melanin produced by the B16 murine melanocyte line

[0080] Cells were incubated with selected components or assay reference (kojic acid, 400 μg / mL) in the presence or absence of NDP-MSH, an analogue of MSH, for 72 hours. The total amount of melanin (extracellular and intracellular) was assessed by measuring the optical density at 405 nm of each sample compared to a melanin standard...

Embodiment 2

[0090] Example 2: Effect of Chichoric Acid and Chicory Extract on Skin Barrier Function and Skin Moisture Content

[0091] The potential beneficial effects of the extract of Example 1 on skin barrier function and skin moisture content were assessed by assessing filaggrin synthesis using 2D cultures of human primary epidermal keratinocytes.

[0092] cell culture conditions

[0093] Culture human epidermal keratinocytes in restricted keratinocyte serum-free medium in a humidified culture chamber at 37 °C with 5% CO 2 cultivated under conditions.

[0094] Synthesis of filaggrin by human epidermal keratinocytes

[0095] Cells were mixed with selected components or assay references (CaCl 2 , 1.5mM) together for 144 hours. Filaggrin production was assessed by immunolabeling.

[0096] result

[0097] The result is as image 3 shown. Pretreatment of cells with chicory extracts MS-55, MS-70 and cichoric acid resulted in an increase in filaggrin, suggesting that these ex...

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Abstract

The present invention relates generally to the field of food products for cosmetic purpose. More specifically, the present invention aims to provide an ingredient containing chicoric acid and / or derivatives for preventing and / or treating hyper-pigmentation of skin, skin color imperfections such as age-spots and other skin disorders characterized by abnormal pigments. The present invention also aims at improving skin tone as well as providing a skin lightening agent.

Description

[0001] The present invention relates generally to the field of food or drink products for cosmetic purposes. More specifically, the present invention aims to provide a composition comprising cichoric acid and / or derivatives for the prevention and / or treatment of hyperpigmentation of the skin, skin spots such as age spots and other skin conditions characterized by abnormal pigmentation disease. It is also an object of the present invention to improve skin tone and to provide skin lightening or lightening agents. Background of the invention [0002] Skin color is primarily determined by the amount and type of melanin, a brown pigment present in the skin. The less the amount of melanin, the whiter the skin, and the more the melanin, the darker the skin. In addition, hyperpigmentation of the skin is also caused by the overexpression or accumulation of melanin in the skin. Therefore, the pathways involved in melanin production have been the target of many inhibitors used to redu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K8/37A61K8/97A61Q19/00A61Q19/02A61Q19/08A23L1/30
CPCA23L1/3002A61Q19/00A23L1/3014A61K31/216A61K8/37A61K36/28A61K8/365A61K2800/884A61K8/97A61Q19/02A61K8/99A61K2800/92A23L33/105A23L33/135A61K8/02A61K2800/88A61K8/9789A61P17/00A61P17/16A61K2236/331
Inventor M·吉塔尔R·贝尔罗里德A·牟迪克里弗F·迪欧尼斯
Owner SOC DES PROD NESTLE SA
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