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Modulation of post - prandial fat absorption

A fat absorption and fat technology, applied in the field of infant formula milk and growing-up milk, can solve problems such as suboptimal and inability to breastfeed and breastfeed

Active Publication Date: 2013-03-06
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are situations where breastfeeding is not possible or is suboptimal

Method used

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  • Modulation of post - prandial fat absorption
  • Modulation of post - prandial fat absorption
  • Modulation of post - prandial fat absorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Embodiment 1: the preparation of experimental infant formula milk

[0129] Prepared by dissolving a premix of demineralized whey powder, lactose, whey protein concentrate, skimmed milk powder, galacto-oligosaccharides, minerals and vitamins in demineralized water to a dry weight content of 22.5g / 100g An aqueous phase was prepared and heated at 65°C. For infant formula (IMF) 3 (a buttermilk powder enriched with milk-derived phospholipids), SM2 (Corman, Beldium) was also added to the aqueous phase.

[0130] An oil blend is prepared using greater than 98% by weight vegetable oil, fat soluble vitamins and antioxidants. Both the water phase and the oil blend were heated to 65°C prior to mixing. The oil blend was added to the water phase and blended with an Ultra-Turrax T50 at 5000-1000 rpm for about 30-60s. The dry weight of this mixture is about 26%. The product was UHT treated at 125°C for 30s and then cooled to 20°C.

[0131] For IMF 1, 2-step homogenization was do...

Embodiment 2

[0142] Example 2: Lipid globule package quilt Postprandial plasma lipid levels and red blood cell membrane fat Programmatic Effects of Acid Composition

[0143] The offspring of C57 / BL6 mice were selected as 4 males and 2 females per litter. On the 15th day, a group of 42 pups were isolated by barriers and fasted for 2 hours. A group of background pups (n=7) were sacrificed and blood and liver samples were collected: t=0 group. After fasting for 2 hours, male pups (n=35) were force-fed with warm soybean oil (0.25ml / pup) at t=0. Pups were sacrificed at t=1, 2, 3, 5 and 8 h after gavage (n=7 at each time point). Body weight and blood samples, liver samples, and fresh (wet) fecal excretions were obtained from each pup.

[0144] The remaining pups were assigned to 3 different experimental diets until day 28. The pups remained in the litter with the barrier until day 21 when the barrier was removed.

[0145] The experimental diet used for weaning was:

[0146] 1) IMF-ba...

Embodiment 3

[0165] Embodiment 3: wrap with phospholipid quilt The size of lipid globules affects the fatty acid groups of red blood cell membranes Cheng's role

[0166] The offspring of C57 / BL6 mice were selected as 4 males and 2 females per litter. On day 15 the pups were assigned to 3 different experimental diets until day 42. The pups remained in the litter with the barrier until day 21 when the barrier was removed.

[0167] The experimental diet used for weaning was:

[0168] 1) Diet based on the IMF of the present invention. The lipid globules were coated and had a mode diameter of 0.28 μm (volume weighted). (2-12μm, 2%)

[0169] 2) Diet based on the IMF of the present invention. The lipid globules were coated and had a mode diameter of 6.77 μm (volume weighted). (2-12μm, 60%)

[0170] Lipid globule size differences were obtained by homogenization pressure differences as described in Example 1. The phospholipid source was SM2 powder from Corman, which was used at a fina...

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Abstract

The invention relates to a method for programming the post-prandial fat handling in an infant by a nutritional composition comprising lipid globules coated with phospholipids.

Description

technical field [0001] The invention belongs to the fields of infant formula milk and growing-up milk. In particular, the present invention relates to nutritional compositions formulated such that they have a sustained effect on fat metabolism responses. Background technique [0002] Breastfeeding is the preferred method of feeding babies. However, there are situations where breastfeeding is not possible or is not ideal. In such cases infant formula is a good substitute. The composition of modern infant formula should meet the many specific nutritional needs of rapidly growing and developing infants. [0003] It still appears that improvements can be made in the composition of infant formula. For example, breastfed infants are known to be less obese later in life than formula-fed infants. And, among subjects who were breastfed during infancy, the lipid profile was healthier later in life. Furthermore, early-life breastfeeding was associated with higher bone density and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/30A23L1/00A23L33/00
CPCA23V2002/00A23L1/296A23L1/30A23L1/3006A23L33/40A23L33/10A23L33/115A23V2200/22A23V2250/1882A23V2250/1842A23V2250/1844A23V2250/1846A23V2250/1848A23V2250/185A23V2250/1852A23V2250/18
Inventor H·J·M·范德海吉恩E·M·范德比克M·阿布拉哈姆瑟-伯克维尔德G·贝姆
Owner NV NUTRICIA
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