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Application of Houttuynoid A in drugs for treating lung cancer

A drug and lung cancer technology, applied in the field of anti-tumor drugs, can solve the problem of damage to normal tissues and cells, and achieve the effect of strong cytotoxicity and prominent substantive characteristics

Inactive Publication Date: 2013-01-30
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application.

Method used

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  • Application of Houttuynoid A in drugs for treating lung cancer
  • Application of Houttuynoid A in drugs for treating lung cancer
  • Application of Houttuynoid A in drugs for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Houttuynoid A tablet involved in the present invention:

[0014] Take 20 grams of compound Houttuynoid A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Houttuynoid A capsule involved in the present invention:

[0016] Get 20 grams of compound Houttuynoid A, add conventional auxiliary materials such as starch 180 grams for preparing capsules, mix well, and pack into capsules to make 1000 tablets.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0018] Experimental example: Houttuynoid A's inhibitory effect on the proliferation of lung cancer cells cultured in vitro and its effect on normal human cells

[0019] Lung cancer cells in the logarithmic growth phase (non-small cell lung cancer cells A 549 , large cell lung cancer cells NCI-H460, lung squamous cell carcinoma cells HTB-8 and human lung squamous cell carcinoma cells QG-5) and human normal liver cells L02 were inoculated on 96-well culture plates, and the seeding volume per well was 3000-4000 Cells / 100uL and 6000 cells / 100uL; aseptically collect 15 mL of venous blood from healthy blood donors, anticoagulate with heparin, separate mononuclear cells by Ficoll density gradient centrifugation, prepare single cell suspension with RPMI1640 containing 10% fetal bovine serum, Adjust the cell concentration to 2×10 5 cells / mL, inoculated in 96-well culture plate, 100 uL per well. After 24 hours of cell culture on the above-mentioned culture plates, the experimental gro...

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Abstract

The invention discloses an application of Houttuynoid A in preparing drugs for treating lung cancer. As a compound, the Houttuynoid A shows high anti-lung cancer activity, can be used for preparing the anti-lung cancer drugs and belongs to the technical field of new uses of the drugs. The Houttuynoid A is capable of remarkably inhibiting non-small cell lung cancer cells A549, large cell lung cancer cells NCI-H460, lung squamous cancer cells HTB-8 and human lung epidermoid carcinoma cells QG-5, but is smaller in effect of inhibiting human normal hepatocytes LO2 and peripheral blood lymphocytes, i.e. obvious selectivity is shown. The application of the Houttuynoid A in preparing the drugs for treating the lung cancer is disclosed for the first time. Moreover, the skeleton type of the Houttuynoid A is fire-new, and how strong the inhibitory activity of the Houttuynoid A on the lung cancer cells is unexpected.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to the application of Houttuynoid A in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application. It has become the direction and urgent task of current anticancer drug research to find highly efficient and low toxic drugs for treating tumors. Finding high-efficiency, low-toxic anticancer drugs has been considered an effective way. [0003] The present invention has confirmed by experiments that Houttuynoid A has the effect on non-small cell lung cancer cell A cultured in vitro. 549 , large cell lung cancer cell line NCI-H460, lung squamous cell carcinoma cell line HTB-8 and human lung squamous epithelial cell line QG-5 have significant inhibitory ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00
Inventor 朱磊磊俞骁吴俊华
Owner 吴俊华
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