Nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation, and preparation method thereof

Abstract

The invention relates to a nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation, and a preparation method thereof, and belongs to the technical field of the foam preparation production. The preparation is composed of a nano-drug, a gel matrix, a surfactant, a cosurfactant, an oil phase, a foaming agent, an antiseptic, a solvent and a propellent. The preparation method comprises the steps of dissolving the gel matrix in deionized water to fully swell into a flow liquid; adding the surfactant and the cosurfactant in residue deionized water; adding the chitosan; stirring and heating to make the chitosan fully dissolved; mixing the above two solutions, adding the antiseptic, adding the nano-silver sol liquid after the mixture becomes uniform, stirring uniformly; weighing the oil phase and the foaming agent, adding the oil phase and the foaming agent to the above liquid, making into an emulsion solution via ultrasonic emulsification; loading the emulsion solution in a pressure bottle; adding the propellent to make the finished product of the nano-silver chitosan gel foam preparation. The gel foam preparation can kill bacteria quickly, is convenient for administration, is low in drug dosage, can decrease side effects, and eliminates potential safety risks caused by large application amount of the nano-silver.

Description

technical field [0001] The invention relates to a gel preparation, in particular to a nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation and a preparation method thereof, and to a new gel system that is a nano-silver chitosan gel foam The preparation and its preparation method belong to the technical field of gel preparation production. Background technique [0002] Female bacterial vaginosis is a common disease of gynecological reproductive tract infection, which seriously affects the physical and mental health of women. There are many reasons for bacterial vaginosis. For example, the body’s body resistance decreases, which is easy to cause infection, and there is also the abuse of antibiotics, resulting in bacterial resistance. More importantly, many female patients often use lotion, which causes female vaginal environment. Damaged, more likely to cause vaginal infection opportunities. [0003] Due to the very high incidence of female ...

AI Technical Summary

Problems solved by technology

[0005] Patent CN101491541B introduces a temperature-sensitive gel-type nano-silver foam aerosol. The material is poloxamer, and the propellant used is dimethyl ether. Since the nano-silver colloid and other liquids in the system are easy to separate, there is a lack of foaming agent and foam stabilizer in this patent. After the actual filling, there will be Insufficient jet foaming and foam instability

The amount of nano-silver used in this patent is too large, which may bring potential safety hazards

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