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Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application

A technology for primary dysmenorrhea and traditional Chinese medicine preparations, applied in non-central analgesics, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of long taking time, lack of clinical research, slow effect, etc.

Inactive Publication Date: 2013-01-09
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of them are biased towards unilateral and proven prescriptions, take a long time, take effect slowly, lack of systematic and perfect clinical research, and lack of research on its mechanism of action

Method used

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  • Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application
  • Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application
  • Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Angelica 36 parts Cumin 30 parts Chuanxiong 12 parts

[0090] Put 10 parts of Radix Paeoniae Rubra and 10 parts of roses into the decoction.

[0091] The above drugs are weighed according to the prescription, and extracted twice with water. For each dose of medicinal materials, add 500mL of water to the first decoction, add 300mL of water to the second decoction, combine the filtrate, concentrate the water extract under reduced pressure to 200ml, and divide it into two bags, each bag 100ml, 1 bag / Time, 2 times / day, orally, take 3-5 doses 3-5 days before menstruation, until the first day of menstrual tide, 3 menstrual cycles are a course of treatment.

Embodiment 2

[0093] Angelica 40 parts Cumin 22 parts Chuanxiong 10 parts

[0094] Put 10 parts of Radix Paeoniae Rubra and 10 parts of roses into the decoction.

[0095] The above medicines are weighed according to the prescription, and extracted twice with water. For each dose of medicinal materials, add 500mL of water to the first decoction, add 300mL of water to the second decoction, combine the filtrate, mix well, sieve, then mix with 300g of starch evenly, and use starch slurry (take 220g of starch) Make starch slurry with water), make granules, sieve, dry, and pack into capsules.

Embodiment 3

[0097] Angelica 38 parts Cumin 18 parts Chuanxiong 14 parts

[0098] Put 8 parts of Radix Paeoniae Rubra and 12 parts of roses into the decoction.

[0099] The above medicines are weighed according to the prescription, (after crushing, heat and reflux with 95% ethanol to extract twice, each time for 2 hours, after filtering, combine the 95% ethanol extract, concentrate the ethanol extract until it has no alcohol smell, and obtain the ethanol extract MSF- A. Extract the ethanol extract with 100mL ethyl acetate, combine multiple extracts with rotary evaporation, concentrate and dry to obtain MSF-A-E, the yield of paste is 2.77%), dissolve in the prescribed amount of ethanol and glycerin at room temperature, stir to dissolve Finally, add some water for injection, stir well, add glucose, stir to dissolve, add water for injection to 1000ml, filter, pot, and sterilize to obtain.

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Abstract

The invention discloses a Chinese medicine preparation for treating primary dysmenorrheal, a preparation method and an application. The Chinese medicine preparation is composed of medicines of angelica, flos rosae rugosae, fennel fruits, ligusticum wallichii, red paenoy roots and the like. On the basis of traditional Chinese medicine syndrome differentiation and treatment theory, the Chinese medicine preparation for treating primary dysmenorrheal is prepared by combining years of clinical experience. The Chinese medicine preparation for treating primary dysmenorrheal is characterized in that according to characteristics of hormonal level change at each stage of a sexual cycle, medicine intervention is performed at the luteal regression stage, two hormone peaks in the whole sexual cycle process can be avoided, relative excited signal molecues at the local position of uterus tissue can be directly confronted, interference for feedback effect on thalamus-hypophysis-ovarian axis sex hormone is weakened, and thereby the effect of treating the primary dysmenorrheal can be exerted. The Chinese medicine preparation for treating the primary dysmenorrheal has special good effects on the diseases of dysmenorrheal and abnormal menstruation and the like caused by kidney energy loss, qi stagnation and blood stasis, congealing cold blood stasis, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach and damp and hot accumulation, the Chinese medicine preparation for treating the primary dysmenorrheal is widely applied to clinic and relieves pains of patients, and the effective rate can reach to 96%.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for treating primary dysmenorrhea, a preparation method and application thereof. Background technique [0002] Primary dysmenorrhea is a common gynecological disease with a high incidence rate. The use of different epidemiological investigation methods shows that the incidence of primary dysmenorrhea is between 20% and 90%, and it is a common cause that affects women's normal work and quality of life. In recent years, domestic and foreign studies on the treatment of primary dysmenorrhea and its mechanism of action have continued to deepen. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used first-line drugs. About 64-100% of patients have relieved subjective symptoms after using these drugs, such as oral indomethacin (Metindo), ibuprofen (Ibuprofen), etc., but these drugs It is eas...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61P15/00A61P29/00
Inventor 方玲
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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