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Method for preparing nine-flavor notopterygium granules

A technology of Qianghuo and granules, applied in the field of preparation of Jiuwei Qianghuo granules, can solve the problems of large dosage for patients, rough process, affecting clinical application, etc., and achieve the effect of reducing the dosage.

Inactive Publication Date: 2012-12-19
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, Jiuwei notopterygium granules are prepared by percolation and water decoction. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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  • Method for preparing nine-flavor notopterygium granules
  • Method for preparing nine-flavor notopterygium granules
  • Method for preparing nine-flavor notopterygium granules

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Take notopterygium 150g, Fangfeng 150g, Cangzhu 150g, Asarum 50g, Chuanxiong 100g, Angelica dahurica 100g, Scutellaria baicalensis 100g, licorice 100g, Rehmannia glutinosa 100g, add notopterygium, Fangfeng, Cangzhu, Asarum, Chuanxiong into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained, and it is used for later use; take Angelica dahurica, Scutellaria baicalensis, licorice, and rehmannia root, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction, with an extraction power of 400W , extracted 2 times, 4 minutes each time, combined the extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected...

Embodiment 2

[0055] Take notopterygium 150g, Fangfeng 150g, Cangzhu 150g, Asarum 50g, Chuanxiong 100g, Angelica dahurica 100g, Scutellaria baicalensis 100g, licorice 100g, Rehmannia glutinosa 100g, add notopterygium, Fangfeng, Cangzhu, Asarum, Chuanxiong into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for later use; take Angelica dahurica, Scutellaria baicalensis, licorice, and rehmannia root, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction with an extraction power of 600W , extracted 2 times, 8 minutes each time, combined the extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the...

Embodiment 3

[0058] Take notopterygium 150g, Fangfeng 150g, Cangzhu 150g, Asarum 50g, Chuanxiong 100g, Angelica dahurica 100g, Scutellaria baicalensis 100g, licorice 100g, Rehmannia glutinosa 100g, add notopterygium, Fangfeng, Cangzhu, Asarum, Chuanxiong into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, and it is used for later use; take Angelica dahurica, Scutellaria baicalensis, licorice, and rehmannia glutinosa, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction, with an extraction power of 500W , extracted twice, 6 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collecte...

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Abstract

The invention provides a method for preparing nine-flavor notopterygium granules. The nine-flavor notopterygium granules are prepared from the bulk pharmaceutical chemicals of 150g of notopterygium, 150g of divaricate saposhnikovia root, 150g of rhizoma atractylodis, 50g of asarum, 100g of rhizoma chuanxiong, 100g of radix angelicae dahuricae, 100g of radix scutellariae, 100g of liquorice and 100g of rehmannia. The invention also discloses an application of the nine-flavor notopterygium granules in the cholagogue aspect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of Jiuwei notopterygium granules. Background technique [0002] Jiuwei Qianghuo Granules is recorded in the Chinese Pharmacopoeia. It is made of 150g of notopterygium, 150g of Fangfeng, 150g of Atractylodes atractylodes, 50g of Asarum, 100g of Chuanxiong, 100g of Angelica dahurica, 100g of Scutellaria baicalensis, 100g of licorice, and 100g of Rehmannia glutinosa. . It is used for aversion to cold and fever caused by exogenous wind-cold and dampness, no sweat, severe headache, and sore limbs. [0003] In the prior art, there is no report on Jiuwei Notopterygium Granules in choleretic effect. [0004] In the prior art, Jiuwei notopterygium granules are prepared by percolation and water decoction. The process is rough and outdated, and there are many impurities, which leads to excessive dosage for patients and is inconvenient...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/16A61P25/04A61P29/00
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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