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Application of drug composition in drug preparation for preventing or treating neovascular diseases

A new blood vessel and composition technology, applied in the field of medicine, can solve the problems that have not been reported in the application, achieve clear blood vessels, significant application value, and reduce the number of vascular endothelial cell nuclei

Active Publication Date: 2012-11-21
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1347714A discloses a pharmaceutical composition for treating diabetic nephropathy, which is composed of astragalus, Ligustrum lucidum, leeches, rhubarb, Radix Pseudostellaria, and Lycium barbarum, but the application of the pharmaceutical composition in the preparation of drugs for inhibiting neovascularization has not been reported yet

Method used

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  • Application of drug composition in drug preparation for preventing or treating neovascular diseases
  • Application of drug composition in drug preparation for preventing or treating neovascular diseases
  • Application of drug composition in drug preparation for preventing or treating neovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1. The inhibitory effect of the pharmaceutical composition on hypoxia-induced retinal neovascularization in young mice

[0033] 1. Test method

[0034] Take 50 C 57 BL / 6J young mice were housed in 2 litters at the age of 2 days, with a total of 4 cages. At the age of 7 days, one mother mouse and young mice in each cage entered the oxygen box, and a total of 4 oxygen boxes (each oxygen box The mice were fed by 2 mothers in turn), and the other mother was raised in normal indoor air, and 2 mothers were exchanged in each oxygen box and cage every day. During the rearing period, the flow rate of oxygen was controlled at 0.50-0.75 L / min, and the oxygen concentration in the container was (75±2)%. Use an oxygen meter to intermittently monitor the oxygen concentration in the container, 4 to 6 times a day, keep the room temperature at (23±2)°C, and feed them in this high-oxygen environment for 5 days. After 5 days (that is, 12 days old), put the pups back to normal Ai...

Embodiment 2

[0051] Example 2, the preventive effect of the pharmaceutical composition on STZ-induced diabetic retinopathy

[0052] 1. Test method

[0053] Take 300 normal male SD rats, raise them in the observation room for 3 days, fast for 24 hours before modeling and weigh them, and inject streptozotocin (Streptozotocin, 0.1mmol / L, pH 4.4 1% STZ in sodium citrate buffer). One week after the injection, blood was taken from the tail, and the fasting blood glucose was measured. Those with fasting blood glucose ≥ 15.8mmol / L were included as diabetic rat models. After raising the diabetic rats for 4 weeks, 80 model rats with stable blood glucose values ​​were selected (blood glucose Value ≥ 15.8mmol / L) and 10 normal group rats.

[0054] Model animal is divided into 6 groups at random by blood sugar level, is respectively model group (equal volume physiological saline), positive group (0.5g Dobes / kg body weight), pharmaceutical composition A group of the present invention (prepared by embod...

Embodiment 3

[0071] Embodiment three, the therapeutic effect of Chinese medicine compound on STZ-induced diabetic retinopathy

[0072] 1. Test method

[0073] Take 300 normal male SD rats, raise them in the observation room for 3 days, fast for 24 hours before modeling and weigh them, and inject streptozotocin (Streptozotocin, 0.1mmol / L, pH 4.4 1% STZ in sodium citrate buffer). One week after the injection, blood was collected from the tail to measure fasting blood glucose. Those with fasting blood glucose ≥ 15.8mmol / L were included as diabetic rat models, and continued to be fed with basal diet for 3 months, and the rat retinal hemodynamic parameters were measured. The abnormality of flow dynamic parameters can be determined as the subclinical stage of diabetic retinopathy in model animals according to the "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine in the Treatment of Diabetic Retinopathy".

[0074] Select 70 rats with diabetic reticulosis, pe...

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Abstract

The invention discloses an application of a drug composition in drug preparation for preventing or treating neovascular diseases, the drug composition is composed of six traditional Chinese medicines of Astragalus mongholicus, radix pseudostellariae, Ligustrum lucidum Ait, wolfberry fruit, leech and rheum officinale.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of a pharmaceutical composition in the preparation of drugs for preventing or treating neovascular diseases. Background technique [0002] Angiogenesis is the biological process of growing new blood vessels on the original vascular structure, which is the result of cell-cell, cell-matrix and cell-cytokine interactions. It has been found in trauma, ischemia, inflammation, tissue Neovascularization can also occur in pathological conditions such as hypoxia, tumor growth, diabetic retinopathy, rheumatoid arthritis, psoriasis, atherosclerosis, and psoriasis. According to relevant literature reports, whether the neovascularization is physiological or pathological, its formation process can be roughly divided into five stages: 1. Increased permeability of endothelial cells (it has been recognized that tissue ischemia and hypoxia are often accompanied by microvascular 2. Disi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P9/00A61P35/00A61P27/02A61P9/10A61P27/06A61P27/10A61P27/12A61K35/62
Inventor 柯尊洪吴建明
Owner SICHUAN JISHENGTANG PHARMLS
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