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Composition for treating cerebral injury and neurodegenerative symptoms

A neurodegenerative disease and composition technology, which is applied in the direction of nervous system diseases, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as inability to effectively obtain neurons and increase the risk of suffering from tumors

Inactive Publication Date: 2012-10-31
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the proliferation and differentiation of neural stem cells are contradictory. Drugs that simply promote the proliferation of neural stem cells not only cannot effectively obtain a certain number of neurons, but also increase the risk of suffering from tumors; blindly promoting the differentiation of neural stem cells also inhibits The proliferation of neural stem cells also does not get enough neurons to replace damaged nerve cells

Method used

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  • Composition for treating cerebral injury and neurodegenerative symptoms
  • Composition for treating cerebral injury and neurodegenerative symptoms
  • Composition for treating cerebral injury and neurodegenerative symptoms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] The prescription of composition of the present invention:

[0074] 50 parts by weight of total salvianolic acid, 0.5 part by weight of baicalin extract, 20 parts by weight of starch, 10 parts by weight of microcrystalline cellulose, and 2 parts by weight of magnesium stearate.

[0075] The extraction of total salvianolic acid comprises the following preparation steps:

[0076] Take Danshen decoction pieces, add water according to 8 times its weight, soak at 80°C for 2 hours, extract twice, combine the extracts, adjust the pH value to 1, let stand for 6 hours, filter, collect the filtrate, and purify it with D101 macroporous resin. First eluted with water to remove polysaccharides, ethanol gradient eluted, collected the eluate of 60% ethanol, and concentrated and dried the eluate to obtain the total salvianolic acid of salvia miltiorrhiza, wherein the total salvianolic acid of salvia miltiorrhiza contains 72% by weight of salvianolic acid B;

[0077] The extraction of ...

Embodiment 2

[0080] The prescription of composition of the present invention:

[0081] 1 part by weight of total salvianolic acid, 50 parts by weight of baicalin extract, 20 parts by weight of starch

[0082] The extraction of total salvianolic acid comprises the following preparation steps:

[0083] Take Danshen decoction pieces, add water according to 10 times its weight, soak at 50°C for 4 hours, extract twice, combine the extracts, adjust the pH value and let stand for 2 hours, filter, collect the filtrate, purify it with D101 macroporous resin, and wash it with water first Remove the polysaccharide, ethanol gradient elution, collect the eluate of 70% ethanol, and concentrate and dry the eluate to obtain the total phenolic acid of Salvia miltiorrhiza, wherein the total phenolic acid of Salvia miltiorrhiza contains 75% by weight of salvianolic acid B;

[0084] The extraction of baicalin extract comprises the following preparation steps:

[0085] Take Scutellaria baicalensis slices, ad...

Embodiment 3

[0087] The prescription of composition of the present invention:

[0088] 10 parts by weight of total salvianolic acid, 20 parts by weight of baicalin extract, 20 parts by weight of polyethylene glycol 6000.

[0089] The extraction of total salvianolic acid comprises the following preparation steps:

[0090] Take Danshen decoction pieces, add water according to 14 times its weight, soak at 90°C for 3 hours, extract twice, combine the extracts, adjust the pH value to 1, let stand for 2 hours, filter, collect the filtrate, and purify it with D101 macroporous resin. First eluted with water to remove polysaccharides, ethanol gradient eluted, collected the eluate of 80% ethanol, concentrated and dried the eluate, and obtained the total salvianolic acid of salvia miltiorrhiza, wherein the total salvianolic acid of salvia miltiorrhiza contains 78% by weight of salvianolic acid B;

[0091] The extraction of baicalin extract comprises the following preparation steps:

[0092] Take S...

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Abstract

The invention discloses a drug composition for treating cerebral injury and neurodegenerative symptoms in a recovery period and sequelae. Salvianolic acids and baicalin extracts are combined to be used in a compatibility manner, and effects of obviously improving local microenvironments and improving limb exercise and cognitive functions are realized. A pharmacology experiment proves that the composition can regulate and control expression of correlation factors of angiogenesis, and improves the local microenvironments. Multiplication of neural stem cells is promoted, the neural stem cells can be induced to be directionally differentiated towards a neuron direction, and functional nerve regeneration is promoted. The Composition containing effective ingredients of traditional Chinese medicines can be prepared into any drug preparations for curing the cerebral injury and the neurodegenerative symptoms.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and relates to a pharmaceutical composition for improving microenvironment, promoting nerve regeneration, and treating brain injury and neurodegenerative diseases and its application. More specifically, by combining salvianolic acid with baicalin extract, a pharmaceutical composition that can improve local microenvironment, promote nerve regeneration, improve limb function and improve cognitive function is prepared. Background technique [0002] Brain injury and neurodegenerative diseases mainly include cerebral hemorrhage / ischemic injury, stroke, ischemic dementia, Alzheimer's disease, Parkinson's disease and traumatic brain injury, etc., with high disability rate, high mortality rate and high recurrence rate and many complications. Early post-brain injury is usually accompanied by symptoms such as loss of neurons in the brain, decline in consciousness, language, l...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P9/10A61P25/16A61P25/24A61P25/28
Inventor 张艳军庄朋伟张密霞国大亮
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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