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Pharmaceutical composition for treating asthma

A composition, a technique for asthma, applied in the field of medicine

Inactive Publication Date: 2012-10-10
王学军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are no reports of using ambroxol hydrochloride and montelukast sodium as active ingredients at home and abroad, interacting, synergizing, and compatible prescriptions for the treatment of asthma and other diseases.

Method used

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  • Pharmaceutical composition for treating asthma
  • Pharmaceutical composition for treating asthma
  • Pharmaceutical composition for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of pharmaceutical composition tablet of the present invention

[0038] 1. Prescription:

[0039] Prescription 1,

[0040] Prescription 2,

[0041]

[0042] Prescription 3,

[0043] 2. Preparation process:

[0044] (1) Take the raw and auxiliary materials according to the prescription amount. Dissolve hypromellose in water to make a 2% aqueous solution for later use.

[0045] (2) Mix the medicinal composition, starch and microcrystalline cellulose evenly, add an appropriate amount of 2% HPMC aqueous solution, and stir evenly to make a suitable soft material.

[0046] (3), cross 20 mesh sieves and make granules.

[0047] (4) The granules are dried under the condition of 60°C.

[0048] (5) Add magnesium stearate and sodium starch glycolate to the dried granules, pass through a 18-mesh sieve for granulation, and mix well.

[0049] (6) Sampling and testing of semi-finished products.

[0050] (7), press the tablet according to t...

Embodiment 2

[0052] Embodiment 2: the preparation of pharmaceutical composition capsule of the present invention

[0053]1. Prescription:

[0054] Prescription 1,

[0055]

[0056] Prescription 2,

[0057] Prescription 3,

[0058] 2. Preparation process:

[0059] (1) Take the raw and auxiliary materials according to the prescription amount. Dissolve hypromellose in water to make a 2% aqueous solution for later use.

[0060] (2) Mix the medicinal composition, starch and microcrystalline cellulose evenly, add an appropriate amount of 2% HPMC aqueous solution, and stir evenly to make a suitable soft material.

[0061] (3), cross 20 mesh sieves and make granules.

[0062] (4) The granules are dried under the condition of 60°C.

[0063] (5), the dried granules are added with magnesium stearate, passed through a 18-mesh sieve for granulation, and mixed evenly.

[0064] (6) Sampling and testing of semi-finished products.

[0065] (7), pack into capsule according to the loading d...

Embodiment 3

[0067] The preparation of embodiment 3 pharmaceutical composition granules of the present invention

[0068] 1. Prescription:

[0069] Prescription 1,

[0070]

[0071] Prescription 2,

[0072] Prescription 3,

[0073] 2. Preparation process:

[0074] (1), the sucrose is pulverized through a 100-mesh sieve for subsequent use.

[0075] (2), take the raw and auxiliary materials according to the prescription quantity.

[0076] (3), the pharmaceutical composition and the sucrose are mixed uniformly with the method of increasing in equal amounts, an appropriate amount of 2% HPMC50% ethanol solution is added, and the mixture is evenly stirred to make a suitable soft material,

[0077] (4), cross 20 mesh sieves and make granules.

[0078] (5) The granules are dried at 60°C.

[0079] (6), dry granules pass through 18 mesh sieves and granulate.

[0080] (7), take a sample, test the content of the main drug in the semi-finished product test granules, and determine the l...

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Abstract

The invention discloses a pharmaceutical composition taking ambroxol hydrochloride and montelukast sodium as active ingredients and the application of the pharmaceutical composition. The composition can be made into oral preparations including tablets, capsules, granules, chewable tablets, oral solutions and dry suspensions. As the ambroxol hydrochloride and the montelukast sodium are synergistic, the composition has an unexpected effect of treating asthma and is very good in application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating asthma and its application, in particular to a pharmaceutical composition with ambroxol and montelukast sodium as active ingredients and its application, which belongs to the field of medicine. Background technique [0002] Asthma is a common disease, frequently-occurring disease. At present, there are about 300 million asthmatics in the world, and about 30 million asthmatics in China. Compared with other countries, the prevalence of asthma in our country is low, but the mortality rate is high, and only 3% of asthmatic patients have achieved complete control. If asthma is not well controlled, it will affect the quality of life of patients more than major diseases such as diabetes and hypertension. Asthma is an important disease that affects people's physical and mental health. If it is not treated in time or standardized, it may be fatal. However, there are not many drugs to choose f...

Claims

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Application Information

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IPC IPC(8): A61K31/47A61P11/06A61K31/137
Inventor 王学军李瑞菊王文彬朱爱国丁蕊艳
Owner 王学军
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