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Lurasidone tablet and preparation method thereof

A technology of lurasidone tablet and lurasidone, which is applied in the field of lurasidone tablet and preparation, can solve the problem of not being able to obtain sufficient immediate release

Inactive Publication Date: 2012-09-26
李兴惠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, because lurasidone is a poorly soluble drug, it cannot obtain sufficient immediate release under many prescription preparation conditions, so there is a report of making it into a preparation containing pregelatinized starch (CN101184489A)

Method used

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  • Lurasidone tablet and preparation method thereof
  • Lurasidone tablet and preparation method thereof
  • Lurasidone tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0045] Embodiment 1-5: preparation tablet of the present invention

[0046] Formula (mg / tablet)

[0047] Component

[0048] Note: *HPMC is prepared as a 5% aqueous solution for use, and the final calculated amount is converted into the dry amount of the adhesive as shown in the formula of each example. For example, 5 in Example 2 uses the indicated adhesive, and the total amount added The amount is 5 mg of HPMC dry product. When there is a similar situation below, it also has a similar meaning. 10 mg of magnesium stearate shown in Example 4 is composed of 8 mg of magnesium stearate and 2 mg of colloidal silicon dioxide.

Embodiment 6-10

[0053] Examples 6-10: Preparation of tablets of the present invention

[0054] Formula (mg / tablet)

[0055] Component

[0056] *PVP K30 is used as a 5% aqueous solution.

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Abstract

The invention discloses a lurasidone tablet and a preparation method thereof. The lurasidone tablet comprises lurasidone shown in the formula (I), cellulose derivative and sugar alcohol. The prepared lurasidone preparation, especially lurasidone tablet, has good release performance and excellent mechanical performance.

Description

technical field [0001] The invention relates to a solid pharmaceutical composition of lurasidone, in particular to a lurasidone tablet and a preparation method. Background technique [0002] Lurasidone hydrochloride (Lurasidone HCl, in the present invention, the hydrochloride of this substance can be referred to as lurasidone) is a new type of atypical antipsychotic, and on October 28, 2010, the U.S. Food and Drug Administration ( FDA) approved its marketing, trade name Latuda, for the treatment of schizophrenia. It is a new antipsychotic drug with dual effects developed by Japan's Sumitomo Pharmaceutical Company. It has high affinity for both 5-HT2A receptors and dopamine D2 receptors. It has significant curative effect on both positive and negative symptoms of psychiatric patients, and studies have reported that lurasidone can improve cognitive function. The recommended starting dose is 40 mg / d, the effective dose range is 40-120 mg / d, and the maximum recommended dose i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/496A61P25/18
Inventor 李兴惠
Owner 李兴惠
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