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Dissolving agent capable of dissolving diclazuril and ethopabate simultaneously and anticoccidial medicinal composition

A technology of diclazuril and dissolving agent, which is applied in the direction of drug combination, anti-infective drugs, active ingredients of heterocyclic compounds, etc. It can solve the problems of difficult feed mixing, lower drug efficacy, and less dosage, and achieve broad market prospects and economical effects

Inactive Publication Date: 2012-09-19
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diclazuril and its synergist coccidiostat are excellent medicines for the prevention and treatment of chicken coccidiosis at present, but both are insoluble in water and cannot be directly dissolved in water for drinking and feeding to chickens; while commercially available diclazuril Zhuli premix (0.5%, 0.2%) has a small dosage and is not easy to mix with the feed, which reduces the efficacy and limits its use in production

Method used

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  • Dissolving agent capable of dissolving diclazuril and ethopabate simultaneously and anticoccidial medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1. In this example, the dissolving agent capable of simultaneously dissolving diclazuril and coccidiophenidate consists of 1 ml tetrahydrofuran and 4.5 ml dimethylformamide.

[0013] The anticoccidial pharmaceutical composition containing the above dissolving agent is composed of the following components: 1 L of dissolving agent, 18 g of diclazuril, and 200 g of coccidiodin.

[0014] The preparation method of the anticoccidiostat medicine composition is as follows: adding diclazuril and coccidiophenidate into the dissolving agent and mixing them evenly.

Embodiment 2

[0015] Example 2. The dissolving agent capable of simultaneously dissolving diclazuril and coccidiophenid ​​in this example consists of 1 ml tetrahydrofuran and 2 ml dimethylformamide.

[0016] The anticoccidial pharmaceutical composition containing the above-mentioned dissolving agent is composed of the following components: 1 L of dissolving agent, 12 g of diclazuril, and 160 g of coccidiodin.

[0017] The preparation method of the anticoccidiostat medicine composition is as follows: adding diclazuril and coccidiophenidate into the dissolving agent and mixing them evenly.

Embodiment 3

[0018] Example 3. In this example, the dissolving agent capable of simultaneously dissolving diclazuril and coccidiophenidate consists of 1 ml tetrahydrofuran and 0.25 ml dimethylformamide.

[0019] The anticoccidial pharmaceutical composition containing the above dissolving agent is composed of the following components: 1 L of dissolving agent, 5 g of diclazuril, and 50 g of coccidiodin.

[0020] The preparation method of the anticoccidiostat medicine composition is as follows: adding diclazuril and coccidiophenidate into the dissolving agent and mixing them evenly.

[0021] The test medicine source that the present invention adopts is as follows:

[0022] Diclazuril API (content 99.9%), Qingdao Fukun Veterinary Drug Raw Materials Co., Ltd.;

[0023] Coccidiophen (ethopabate) (content 99.7%), Qingdao Fukun Veterinary Drug Raw Materials Co., Ltd.;

[0024] Tetrahydrofuran (analytical pure), Tianjin Damao Chemical Reagent Factory;

[0025] Dimethylformamide (analytical pure)...

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Abstract

The invention discloses a dissolving agent capable of dissolving diclazuril and ethopabate simultaneously and an anticoccidial medicinal composition. The dissolving agent consists of tetrahydrofuran and dimethylfomamide, and can be used for well dissolving diclazuril and ethopabate; and the production problem that diclazuril and ethopabate are dissoluble in water while an ordinary anticoccidial premixing agent is difficult to mix uniformly in a feed is solved. The anticoccidial medicinal composition prepared by using the dissolving agent contains high concentration diclazuril and ethopabate, and has low toxicity; a solution is stable in an environment of which the temperature is over 4 DEG C; crystal substances are precipitated out in a low-temperature environment; and crystal substances can be dissolved by heating to 65 DEG C and preserving heat for 15 minutes or heating to 25 DEG C and preserving heat for 80 minutes, and the solution becomes clear. Due to the adoption of the dissolving agent, diclazuril and ethopabate can be administrated effectively by drinking water; and the dissolving agent is simple, convenient and effective, and has a wide market prospect and high economic benefit.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a dissolving agent capable of simultaneously dissolving diclazuril and coccidiophenidate and an anticoccidial drug composition. Background technique [0002] Chicken coccidiosis is a chicken parasitic disease caused by Eimeria coccidiosis. It is a global protozoan disease. It is one of the most frequent, serious and difficult diseases in large-scale and intensive chicken farming. , is also one of the most economically costly diseases among all animal diseases. The disease has been listed by the United States Department of Agriculture as one of the most serious diseases in poultry. Chicken coccidiosis is very serious to the harm of chickens and chickens, and the incidence rate of chickens at the age of 15-50 is high, and the mortality rate is as high as more than 80%. The chicks that have endured grow slowly and are stunted; most of the adult chickens are worm carriers, and thei...

Claims

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Application Information

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IPC IPC(8): A61K47/22A61K47/18A61K31/618A61P33/02A61K31/53
Inventor 王宏伟周变华李帅鹏杨自军张才汪纪仓林霖
Owner HENAN UNIV OF SCI & TECH
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