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Process for preparing chloranthalactone A

A technology for golden sulan lactone and salivary lactone, which is applied in the field of preparing golden sulan lactone A by high-speed countercurrent chromatography, can solve the problems of large solvent capacity, long preparation period, large sample loss, etc. Short, sample-free effect

Inactive Publication Date: 2012-09-12
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the separation and purification methods of these methods have defects such as large sample loss, large solvent capacity, and long preparation cycle.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Silverwort is crushed and soaked in 5 times the amount of 95% methanol to extract three times. The concentrated extract is dispersed in water and added to D101 macroporous resin for adsorption. It is eluted with 50% methanol solution and the eluent is concentrated to obtain silverwort extract. Take petroleum ether, ethyl acetate, methanol and water solvents, mix them in a ratio of 1:5:2:6, and after fully layering, take the upper phase as the stationary phase and fill the high-speed countercurrent chromatography tube, turn the host at 800rpm, and pump into the lower phase As the mobile phase, after the dynamic equilibrium, the flow rate is adjusted to 2ml / min, and the extract is dissolved with the mobile phase at the same time, the sample is injected by the injection valve, and the ultraviolet detector is detected online, and the target components are collected according to the spectrum. Continuous preparation, recovery of reagents, reduction of Pressed and dried to obta...

Embodiment 2

[0015] Crush silvergrass, add 8 times the amount of 95% methanol to soak and extract twice, concentrate the extract, disperse it with water, add it to AB-8 macroporous resin for adsorption, elute with 50% methanol solution, concentrate the eluent, and get the extract of silverwort . Take petroleum ether, ethyl acetate, methanol and water solvents, mix them in a ratio of 2:9:3:8, and after fully layered, take the upper phase as the stationary phase and fill the high-speed countercurrent chromatography tube, turn the host at 900rpm, and pump into the lower phase As the mobile phase, after the dynamic balance, the flow rate is adjusted to 3ml / min, and the extract is dissolved with the mobile phase at the same time, the sample is injected by the injection valve, and the ultraviolet detector is detected online, and the target components are collected according to the spectrum, continuously prepared, and the reagent is recovered. Pressed and dried to obtain white Chrysanthemum lacto...

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PUM

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Abstract

The invention discloses a process for preparing chloranthalactone A. The process includes the steps of purifying Chloranthus japonicus Sieb. extractives by using the high-speed counter-current chromatography, subjecting to online detection with an ultraviolet detector, collecting compositions according to maps, and preparing the chloranthalactone A once. The process has the advantages of being efficient, fast and large in preparation quantity and is applicable to preparation of the chloranthalactone A.

Description

technical field [0001] The present invention relates to a kind of preparation method of azuranolide A, particularly relate to a kind of method of utilizing high-speed countercurrent chromatography to prepare azuranolide A. Background technique [0002] Silver thread grass (Chloranthus japonicus Sieb.), also known as Guiduyou, is the whole plant or root and rhizome of Chloranthus japonicus Sieb. It was first recorded in "Shen Nong's Materia Medica", and it is also known as solitary grass, ghost solitary grass, four heavenly kings, four-leaf gold, four-leaf pair, four-leaf clover, four tiles, lantern flower, etc. It is generally believed in modern times that silvertracea is pungent and bitter in taste, warm in nature and poisonous. It has the effects of promoting blood circulation and removing blood stasis, expelling wind and dampness, and detoxification. Folks are used for the treatment of bruises, rheumatic arthralgia, wind-cold cold, swollen sores, and snake bites. As ea...

Claims

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Application Information

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IPC IPC(8): C07D307/77
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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