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Kalii dehydrographolidi succinas freeze-dried powder compound for injection and preparation method thereof

A technology of Chuanhuning and its composition, which is applied in the field of Chuanhuning freeze-dried powder composition for injection and its preparation, can solve the problems of slow response to asthmatic pneumonia in children, achieve enhanced rehydration (dissolution), promote sedation, and improve stability sexual effect

Inactive Publication Date: 2012-09-12
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing drugs for children with wheezing pneumonia are slow to respond

Method used

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  • Kalii dehydrographolidi succinas freeze-dried powder compound for injection and preparation method thereof
  • Kalii dehydrographolidi succinas freeze-dried powder compound for injection and preparation method thereof
  • Kalii dehydrographolidi succinas freeze-dried powder compound for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, Chuanhuning freeze-dried powder composition for injection, in 1000 pieces

[0022] prescription:

[0023]

[0024] Preparation Process:

[0025] 1) Put the prescribed amount of Chuanhuning, ribavirin, and sodium bicarbonate into a preparation tank, add water for injection, stir to dissolve and mix evenly, add 0.05% activated carbon and stir for 30 minutes. Adjust the pH value to 6.5-6.7, and then perform decarburization circulation filtration through a titanium rod for 30 minutes.

[0026] 2) Pass the medicinal liquid obtained in step 1) through 0.45 μm and 0.22 μm filters for 30 minutes to sterilize and circulate. After the sampling inspection meets the requirements, it is filled to determine the filling volume, and the butyl rubber stopper for freeze-drying is half buckled after the filling volume is qualified.

[0027] 3) Put it into a freeze-drying box and carry out vacuum freeze-drying treatment to obtain the Chuanhuning freeze-dried powder comp...

Embodiment 2

[0028] Embodiment 2, Chuanhuning freeze-dried powder composition for injection, in 1000 pieces

[0029] prescription:

[0030]

[0031] Preparation Process:

[0032] 1) Put the prescribed amount of Chuanhuning, ribavirin, and sodium bicarbonate into a preparation tank, add water for injection, stir to dissolve and mix evenly, add 0.05% activated carbon and stir for 30 minutes. Adjust the pH value to 6.5-6.7, and then perform decarburization circulation filtration through a titanium rod for 30 minutes.

[0033] 2) Pass the medicinal liquid obtained in step 1) through 0.45 μm and 0.22 μm filters for 30 minutes to sterilize and circulate. After the sampling inspection meets the requirements, it is filled to determine the filling volume, and the butyl rubber stopper for freeze-drying is half buckled after the filling volume is qualified.

[0034] 3) Put it into a freeze-drying box and carry out vacuum freeze-drying treatment to obtain the Chuanhuning freeze-dried powder comp...

Embodiment 3

[0035] Embodiment three, Chuanhuning freeze-dried powder composition for injection, in 1000 pieces

[0036] prescription:

[0037]

[0038] Preparation Process:

[0039] 1) Put the prescribed amount of Chuanhuning, ribavirin, and sodium bicarbonate into a preparation tank, add water for injection, stir to dissolve and mix evenly, add 0.05% activated carbon and stir for 30 minutes. Adjust the pH value to 6.5-6.7, and then perform decarburization circulation filtration through a titanium rod for 30 minutes.

[0040] 2) Pass the medicinal liquid obtained in step 1) through 0.45 μm and 0.22 μm filters for 30 minutes to sterilize and circulate. After the sampling inspection meets the requirements, it is filled to determine the filling volume, and the butyl rubber stopper for freeze-drying is half buckled after the filling volume is qualified.

[0041] 3) Put it into a freeze-drying box and carry out vacuum freeze-drying treatment to obtain the Chuanhuning freeze-dried powder ...

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Abstract

The invention discloses a kalii dehydrographolidi succinas freeze-dried powder compound for injection and a preparation method thereof and relates to the field of medicines. The compound comprises the following active ingredients: 0.1%-99.9% of kalii dehydrographolidi succinas and 99.9%-0.1% of ribavirin. The preparation method of the freeze-dried powder compound for injection comprises the following specific operation steps: directly adding prescription doses of kalii dehydrographolidi succinas and ribavirin and 0.1-50% of another active ingredient such as sodium bicarbonate in water for injection; adding 0.1% of activated carbon and mixing for 30 minutes; adjusting the pH value to 6.5-6.7; then carrying out decarburization circulating filtration through a titanium rod for 30 minutes; afterwards, carrying out degerming circulating filtration through a 0.45 mu m of filter and a 0.22 mu m of filter for 30 minutes; sampling for inspection, filling after the sample meets the requirements and determining filling volume; after filling volume difference is qualified, half-buckling a butyl rubber plug for freeze-drying and putting the product in a freeze-drying box; and after freeze-drying is completed, obtaining the kalii dehydrographolidi succinas freeze-dried powder compound for injection. The preparation method disclosed by the invention has the advantages of being convenient in liquid processing, simplifying the aseptic operation process, improving the stability of the preparation, removing moisture in the product without thermal treatment, and enhancing the reconstitution property (dissolubility) of the preparation.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a chuanhuning freeze-dried powder composition for injection and a preparation method thereof. Background technique: [0002] If there is a carrier in the newborn's contacts, the newborn is easily infected and causes pneumonia; the newborn is infected with pneumonia through blood circulation due to sepsis, omphalitis, and enteritis, and this infection can be caused by bacteria; In newborns, pneumonia can also be caused by viruses and other microorganisms. The existing drugs for the treatment of asthmatic pneumonia in children are slow to take effect. Invention content: [0003] The object of the present invention is to provide a chuanhuning freeze-dried powder composition for injection and a preparation method thereof, which can efficiently treat asthmatic pneumonia in children. [0004] Concrete technical scheme of the present invention is: [0005] A chuanhuning freeze-dried powder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K9/19A61P11/00A61P31/12A61P31/16A61K31/365
Inventor 汪金灿汪六一李祖红
Owner HAINAN WEI KANG PHARMA QIANSHAN
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