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Traditional Chinese medicinal composition (compound safflower drink) for treating cerebral trauma and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and preparation for treating brain trauma

Inactive Publication Date: 2012-05-09
SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report about the oral preparation composed of the water extract of this prescription as the main active ingredient and pharmaceutical excipients in the treatment of brain trauma

Method used

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  • Traditional Chinese medicinal composition (compound safflower drink) for treating cerebral trauma and preparation method thereof
  • Traditional Chinese medicinal composition (compound safflower drink) for treating cerebral trauma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Effects of Different Chinese Medicine Prescription Extracts on Craniocerebral Injury (Rats)

[0021] The purpose of the experiment: To make a model of craniocerebral injury in rats by using the free-falling method, and to observe the effects of extracts obtained from different traditional Chinese medicine prescriptions on craniocerebral injury.

[0022] 1. Method

[0023] 1.1 Test drug preparation

[0024] Prescription 1: 10g saffron, 120g Chuanxiong, 100g Shichangpu, 30g leech, 120g Eucommia, 120g rehmannia.

[0025] Preparation method: decoct the above six flavors with water twice, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.1-1.15 (80°C), let it cool, add ethanol to make the alcohol content reach 60% , stir well, stand still for 24 hours, filter, recover ethanol from the filtrate and concentrate to a clear paste with a relative density of 1.15-1.2 (80°C), add flavoring agent, add water to 1000 ...

Embodiment 2

[0038] Example 2: Effects of different traditional Chinese medicine prescriptions on cerebral hemorrhage in rats

[0039] Purpose of the experiment: To make a model of cerebral hemorrhage in rats by intracerebral injection of collagenase, and to observe the effects of extracts obtained from different traditional Chinese medicine prescriptions on hemiplegic behavior of cerebral hemorrhage.

[0040] 1. Method

[0041] 1.1 Test drug preparation

[0042] Prescription 1: with embodiment 1.

[0043] Preparation method: with embodiment 1.

[0044] Prescription 2: Same as Example 1

[0045] Preparation method: with embodiment 1.

[0046] 1.2 Grouping and administration: The animals successfully modeled were randomly divided into 4 groups, namely the model group, the blank control group, the prescription 1 treatment group (2.0g / kg), and the prescription 2 treatment group (2.0g / kg). Oral administration, twice a day (1ml / 100g body weight of each rat), for 4 consecutive days. Three ...

Embodiment 3

[0057] Embodiment 3: Granule preparation

[0058] Six-flavored traditional Chinese medicine decoction pieces, decoct twice with water, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.1-1.15 (80°C), let it cool, add ethanol to make the alcohol content reach 60%, stir Evenly, let it stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to a clear paste with a relative density of 1.10-1.15 (80°C), spray dry (inlet air temperature 170°C), and obtain a dry powder; take 500g of the above dry powder, Mix 150g of sucrose and 100g of dextrin evenly, use an appropriate amount of 95% ethanol as a wetting agent, wet granulate, sieve, dry, and pack into 6g / bag granules.

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Abstract

The invention discloses a traditional Chinese medicinal composition (a compound safflower drink) for treating the cerebral trauma and a preparation method thereof. The traditional Chinese medicinal composition disclosed in the invention is a preparation which comprises: a main active component water extract from Crocus sativus, Ligusticum wallichii, Acorus gramineus, Eucommia ulmoides and prepared rehmannia root; and a pharmaceutic adjuvant. The preparation which has a clear curative effect on patients suffering from the cerebral trauma has unique advantages on the treatment of the secondary brain damage.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition (compound safflower decoction) for treating brain trauma and a preparation method. Background technique [0002] Brain trauma (Traumatic brain injury, TBI), especially severe traumatic brain injury (Severe traumatic brain injury, STBI) is the most important cause of human traumatic death and a serious threat to human health, so it has become the focus and focus of research in the field of neurosurgery. difficulty. Western medicine for the treatment of traumatic brain injury requires comprehensive treatment such as oxygen supply, dehydration, hormones, calcium antagonists, infection prevention, symptomatic treatment, nutritional support, and maintenance of water and electrolyte balance. However, Western medicine treatment alone often produces side effects. For example, dehydration with mannitol to reduce intracranial pressure...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P25/00A61K35/62
Inventor 别晓东
Owner SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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