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Method for separating beeswax in propolis through supercritical CO2

A supercritical and propolis technology, which is applied to the recovery/refining of medical preparations containing active ingredients, pharmaceutical formulas, and fatty substances. It can solve the problems of active ingredient reduction and quality reduction of propolis extracts, and achieve the effect of improving quality.

Inactive Publication Date: 2012-03-14
JIANGSU JIANGDAYUAN ECOLOGICAL BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, in order to obtain more pure propolis, dewaxing treatment will be carried out when extracting propolis. Chinese patent documents disclose some dewaxing processes, such as patent No. Method and use", discloses the method of removing beeswax with petroleum ether, the natural propolis is crushed and added into water, soaked and extracted after being fully stirred, then solid-liquid separation is carried out, and the solid is refluxed with petroleum ether to extract the beeswax Wax removal, although this method can remove wax, it is easy to reduce other active ingredients in propolis raw materials, and greatly reduce the quality of propolis extract

Method used

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  • Method for separating beeswax in propolis through supercritical CO2
  • Method for separating beeswax in propolis through supercritical CO2

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 500g of propolis, freeze and pulverize to 14 mesh to form powder, put the propolis pulverized into powder into extraction kettle 1, pass into supercritical CO 2 The fluid is extracted under the conditions of extraction pressure 10Mpa and extraction tank temperature 34°C, and then separated in the separation tank 2 under the conditions of separation pressure 8Mpa and separation temperature 45°C, supercritical CO 2 The flow rate of fluid is 320L / h, and after extracting 1 hour, emits pure white beeswax in separating kettle 2, and beeswax total amount is 130g, and the separated CO 2 The gas is filtered through two-stage filters 3 and 4 to filter out impurities to obtain pure CO 2 Gas, for re-use, CO 2 The gas is then pressurized by the compressor 6, and after being cooled by the cold box 7, the tank body 5 is recycled through the high-pressure pump 8 and the mixer 9. The separation rate of beeswax refers to the proportion (weight ratio) of the separated beeswax in t...

Embodiment 2

[0020] Weigh 500g of propolis, freeze and pulverize to 14 mesh to form powder, put the propolis pulverized into powder into extraction kettle 1, pass into supercritical CO 2 The fluid is extracted under the conditions of extraction pressure 15Mpa and extraction temperature 36°C, and then separated in the separation tank 2 under the conditions of separation pressure 10Mpa and separation temperature 48°C, supercritical CO 2 The flow rate of fluid is 350L / h, and after extracting for 2 hours, the separation kettle emits pure white beeswax, the total amount of beeswax is 145g, and the separated CO 2 The gas is filtered through two-stage filters 3 and 4 to filter out impurities to obtain pure CO 2 Gas, for re-use, CO 2 The gas is then pressurized by the compressor 6, cooled by the cold box 7, and recycled by the high-pressure pump 8 and the mixer 9.

[0021] Performance index: The separation rate of beeswax reaches 97%, and the content of flavonoids and terpenes is zero.

Embodiment 3

[0023] Weigh 500g of propolis, freeze and pulverize to 14 mesh to form powder, put the propolis pulverized into powder into extraction kettle 1, pass into supercritical CO 2 The fluid is extracted under the conditions of extraction pressure 20Mpa and extraction temperature 40°C, and then separated in the separation tank 2 under the conditions of separation pressure 10Mpa and separation temperature 50°C, supercritical CO 2 The flow rate of fluid is 350L / h, and after extracting for 2 hours, the separation kettle emits pure white beeswax, the total amount is 215g, and the separated CO 2 The gas is filtered through two-stage filters 3 and 4 to filter out impurities to obtain pure CO 2 Gas, for re-use, CO 2 The gas is then pressurized by the compressor 6, cooled by the cold box 7, and recycled by the high-pressure pump 8 and the mixer 9.

[0024] Performance indicators: The separation rate of beeswax is greater than 100%, which contains a small amount of flavonoids and terpenes. ...

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Abstract

The invention discloses a method for separating beeswax in propolis through supercritical CO2, which comprises the following steps: carrying out cryogenic crushing on propolis raw material; then extracting with CO2 in an extraction kettle; and separating out white beeswax through a separator. By utilizing the supercritical fluid to extract and separate the beeswax component in propolis at low pressure, the method preserves other active components in the propolis raw material and is not involved with the carrying of any organic solvent, thereby greatly improving the quality of propolis extract.

Description

technical field [0001] The invention relates to a method for separating beeswax from propolis, in particular to a method utilizing supercritical CO 2 The invention relates to a method for separating beeswax components in propolis raw materials under low-pressure fluid, and belongs to the technical field of propolis extraction. Background technique [0002] Beeswax, also called beeswax, is a kind of natural animal wax discovered and utilized by human beings. It is a complex organic substance secreted by the wax glands of worker bees. The main components of beeswax are esters formed by higher fatty acids and higher monohydric alcohols. The chemical composition of beeswax is also different due to different places of origin, bee species, types and processing methods. Beeswax is a fatty substance secreted by the wax glands of workers about two weeks old. Bees absorb honey, a liquid secreted by a series of changes in the wax-secreting organ-the wax gland, which condenses into ...

Claims

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Application Information

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IPC IPC(8): A61K35/64C11B11/00A61K35/644
CPCY02W30/74
Inventor 毛日文邵兴军蒋芸芸
Owner JIANGSU JIANGDAYUAN ECOLOGICAL BIOLOGICAL TECH
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