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Lidocaine hydrochloride transdermal ointment and preparation method thereof

A lidocaine hydrochloride transdermal technology, which is applied in the field of medicine, can solve the problems of low skin penetration rate of lidocaine, and achieve the effects of low price, high antioxidant capacity, and good skin softening properties

Inactive Publication Date: 2012-11-21
张志堂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But above-mentioned transdermal enhancer is lower to the skin permeation rate of medicine lidocaine hydrochloride, as the mixed transdermal enhancer that 5% propylene glycol, 5% urea and 0.5% menthol are formed is to the medicine in lidocaine cataplasm. The utilization rate of lidocaine has 9.74%, and the mixed transdermal enhancer that 15% propylene glycol, 5% urea and 1% menthol forms has only 2.23% to the utilization rate of medicine in lidocaine cataplasm (Liu Tingting, Zeng Fanbo, Lu Zhe, Wait

Method used

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  • Lidocaine hydrochloride transdermal ointment and preparation method thereof
  • Lidocaine hydrochloride transdermal ointment and preparation method thereof
  • Lidocaine hydrochloride transdermal ointment and preparation method thereof

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Effect test

Embodiment 1

[0037] A lidocaine hydrochloride transdermal ointment is composed of a lidocaine hydrochloride ointment and a transdermal accelerator, wherein the transdermal accelerator includes mango butter and menthol.

[0038] The preparation method of lidocaine hydrochloride transdermal ointment, its steps are as follows:

[0039] (1) Mix 8g of mango butter, 2g of menthol, 1.4g of glyceryl monostearate, 2.4g of liquid paraffin, 0.4g of vaseline, and 2g of lanolin, and heat to 80°C to melt after mixing to make oil Mutually;

[0040] (2) Under the condition of 80° C., 0.16 g of triethanolamine, 3 g of lidocaine hydrochloride, and 0.04 g of ethylparaben were dissolved in 40 g of water to make an aqueous phase;

[0041] (3) Pour the water phase of step (2) into the oil phase of step (1), and make lidocaine hydrochloride transdermal ointment after stirring.

Embodiment 2

[0043] A lidocaine hydrochloride transdermal ointment is composed of a lidocaine hydrochloride ointment and a transdermal accelerator, wherein the transdermal accelerator includes mango butter and menthol.

[0044] The preparation method of lidocaine hydrochloride transdermal ointment, its steps are as follows:

[0045] (1) Heat 8g of mango butter, 2g of menthol, 2g of glyceryl monostearate, 4g of liquid paraffin, 1g of petrolatum, and 4g of lanolin to 70-80°C and mix and melt to make an oil phase ;

[0046] (2) Under the condition of 80° C., 0.2 g of triethanolamine, 5 g of lidocaine hydrochloride, and 0.1 g of ethylparaben were dissolved in 75 g of water to prepare an aqueous phase;

[0047] (3) Pour the water phase of step (2) into the oil phase of step (1), and make lidocaine hydrochloride transdermal ointment after stirring.

Embodiment 3

[0049] A lidocaine hydrochloride transdermal ointment is composed of a lidocaine hydrochloride ointment and a transdermal accelerator, wherein the transdermal accelerator includes mango butter and menthol.

[0050] The preparation method of lidocaine hydrochloride transdermal ointment, its steps are as follows:

[0051] (1) 6g of mango butter, 1g of menthol, 1g of glyceryl monostearate, 2g of liquid paraffin, 0.2g of vaseline, and 1g of lanolin are heated to 70°C and mixed and melted to form an oil phase;

[0052] (2) Under the condition of 70° C., 0.1 g of triethanolamine, 2 g of lidocaine hydrochloride, and 0.02 g of ethylparaben were dissolved in 15 g of water to prepare an aqueous phase;

[0053] (3) Pour the water phase of step (2) into the oil phase of step (1), and make lidocaine hydrochloride transdermal ointment after stirring.

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Abstract

The invention discloses a lidocaine hydrochloride transdermal ointment, comprising a lidocaine hydrochloride paste agent and a transdermal enhancer, wherein the transdermal enhancer consists of mango butter and menthol. Because of the synergism of the mango butter and menthol, the lidocaine hydrochloride has high transdermal efficiency reaching 17.09%, good skin softening property and high oxidation resistance, functions of softening skin, smoothing, moisturizing and protecting skin and low price.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a lidocaine hydrochloride transdermal ointment and a preparation method thereof. technical background [0002] Transdermal drug delivery system refers to drug delivery on the surface of the skin, so that the drug can penetrate the skin at a certain rate and enter the blood circulation of the human body to produce local or systemic curative effect. Because this type of preparation can effectively avoid the first-pass effect of the liver and the degradation of the drug by the gastrointestinal tract, and reduce the adverse reaction of the drug, it is a hot spot in the research and development of the third-generation drug preparation. Due to the structure of the skin, it is difficult for drugs to diffuse, penetrate, infiltrate and absorb. Increasing the effective area of ​​the transdermal drug delivery system and increasing the scalp rate of the drug can promote the transdermal abs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/167A61K47/10A61K47/14A61K47/44A61P23/02A61K47/18
Inventor 翟红波李军
Owner 张志堂
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