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Triptolide and lonicerin compatible medicine composition, preparation and application thereof

A technology of triptolide and Lonicera, which is applied in the field of pharmaceutical compositions compatible with Triptolide and Lonicera, and can solve problems such as unsafe clinical medication

Inactive Publication Date: 2012-01-25
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time it is a highly toxic drug, LD 50 The (half lethal dose) is about 0.8mg / kg (orally administered to mice), and has toxicity to multiple organs such as liver and kidney. Application in the treatment of diseases caused by autoimmune system abnormalities such as rheumatoid arthritis, malignant tumors and organ rejection, etc.

Method used

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  • Triptolide and lonicerin compatible medicine composition, preparation and application thereof
  • Triptolide and lonicerin compatible medicine composition, preparation and application thereof
  • Triptolide and lonicerin compatible medicine composition, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Take 1g of triptolide and 1mg of Lonicera and mix uniformly to obtain a pharmaceutical composition, and add suitable pharmaceutical excipients to the pharmaceutical composition to make a pharmaceutically acceptable dosage form, such as tablets, capsules, oral liquids, tinctures, Granules, ointments, injections, emulsions, dripping pills, sustained-release and controlled-release preparations, pharmaceutical compositions and preparations thereof are used as drugs for treating rheumatoid arthritis, antitumor, immunosuppression and anti-inflammation.

Embodiment 2

[0010] Take 1 g of triptolide and 1 g of Lonicera and mix uniformly to obtain a pharmaceutical composition, and add suitable pharmaceutical excipients to the pharmaceutical composition to make a pharmaceutically acceptable dosage form, such as tablet, capsule, oral liquid, tincture, Granules, ointments, injections, emulsions, dripping pills, sustained-release and controlled-release preparations, pharmaceutical compositions and preparations thereof are used as drugs for treating rheumatoid arthritis, antitumor, immunosuppression and anti-inflammation.

Embodiment 3

[0012] Take 1 g of triptolide and 100 g of honeysuckle evenly to obtain a pharmaceutical composition, and add suitable pharmaceutical excipients to the pharmaceutical composition to make a pharmaceutically acceptable dosage form, such as tablet, capsule, oral liquid, tincture, granule, etc. Agents, ointments, injections, emulsions, dripping pills, sustained-release and controlled-release preparations, pharmaceutical compositions and preparations thereof are used as drugs for treating rheumatoid arthritis, anti-tumor, immunosuppression and anti-inflammation.

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PUM

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Abstract

The invention discloses a triptolide and lonicerin compatible medicine composition, a preparation and an application thereof, belonging to the field of medicines. The medicine composition is prepared from the following bulk pharmaceutical chemicals in parts by weight: 1 part of triptolide and 10<-3>-10<5> parts of lonicerin through the step of uniformly mixing, wherein the lonicerin has a chemical name of 3',4',-5,7-tetrahydroxy flavones-7-O-alpha-L-rhamnose (1->2)-beta-D-glucoside. The medicine composition is applied to the preparation of the medicine for treating rheumatoid arthritis, tumors, immunodepression and inflammation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition compatible with triptolide and honeysuckle, as well as its preparation and application. Background technique [0002] Triptolide is an epoxidized diterpene lactone compound isolated from the traditional Chinese medicine Tripterygium wilfordii Hook.f., and is one of the main active ingredients of Tripterygium wilfordii Hook.f. Triptolide has strong pharmacological activity and has significant immunosuppressive, anti-inflammatory, anti-tumor and anti-fertility effects. It is mainly used clinically to treat rheumatoid arthritis, lupus erythematosus, skin diseases, malignant tumors, nephritis and organ Rejection and more than 50 diseases. But at the same time it is a highly toxic drug, LD 50 The (half lethal dose) is about 0.8mg / kg (orally administered to mice), and has toxicity to multiple organs such as liver and kidney. It is used in the treatmen...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/585A61P29/00A61P19/02A61P35/00A61P37/06
Inventor 刘建群舒积成张锐张维潘景行任晓静
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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