Dimeric avermectin and milbemycin derivatives

Abstract

This invention provides for novel antiparasitic and pesticidal derivatives of avermectin and milbemycin compounds in which two avermectin or milbemycin members are linked together by a chemical linker. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections and infestations in animals or for combating pests in plants or plant propagation material.

Description

[0001] Cross references to related applications [0002] This application claims the priority benefit of US Provisional Patent Application No. 61 / 119,761 filed on December 4, 2008, which is incorporated herein by reference in its entirety. Technical field [0003] The present invention provides new antiparasitic derivatives of the avermectin and milbemycin families, in which two avermectin or milbemycin molecules pass through a chemical linker ( linker) connected. The obtained compounds can be used in oral, parenteral or topical veterinary preparations for the treatment, control and prevention of mammals (such as horses, cows, sheep, pigs, dogs, cats and humans, as well as poultry and fish) Endoparasite (endoparasite) and ectoparasite (ectoparasite) infection / infestation. Background technique [0004] Animals and humans suffer from endoparasitic infections, including, for example, helminthiasis most commonly caused by a collection of parasitic worms described as nematodes or round...

AI Technical Summary

Problems solved by technology

Separation of "a" and "b" components can be achieved by standard chromatographic techniques, however, this is rarely done in practice because the R of these derivatives 2 Small differences in substituents have little effect on the chemical reactivity or biological activity of the compound

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