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Application of Platycodon grandiflorum total saponins in the treatment and prevention of mycoplasma pneumoniae infectious diseases

A technology for infectious diseases and Mycoplasma pneumoniae, which is applied in the field of application of Platycodon grandiflorum total saponins in the treatment and prevention of Mycoplasma pneumoniae infectious diseases. It can solve the problems of affecting economic benefits, exceeding the standard of antibiotic content, and long course of treatment, so as to avoid exceeding the standard of antibiotics Effect

Active Publication Date: 2011-12-14
黑龙江省中医研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the treatment of livestock MP infection, due to the long course of treatment for MP infection (about 2 weeks), long-term use of antibiotics will cause a large amount of accumulation in the animal body, resulting in antibiotics in animal muscle, fat, viscera and other tissues and by-products such as milk and eggs. Exceeding the standard will directly affect the economic benefits

Method used

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  • Application of Platycodon grandiflorum total saponins in the treatment and prevention of mycoplasma pneumoniae infectious diseases
  • Application of Platycodon grandiflorum total saponins in the treatment and prevention of mycoplasma pneumoniae infectious diseases
  • Application of Platycodon grandiflorum total saponins in the treatment and prevention of mycoplasma pneumoniae infectious diseases

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Experimental program
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Effect test

specific Embodiment approach 1

[0013] Specific embodiment one: the application of the total platycodon saponins in the medicine for the treatment and prevention of Mycoplasma pneumoniae infectious diseases in this embodiment: The total platycodonoid saponins are used as active ingredients in the medicine for the treatment and prevention of Mycoplasma pneumoniae infectious diseases, and the total platycodon saponins are platycodon acids , telegalic acids, bellflower diacids, bellflower acid A lactone saponins or one or more compositions.

[0014] When the total platycodon saponins are composed of two or more substances, they are mixed in any ratio.

[0015] The anti-MP test of Platycodon grandiflora total saponins in vitro is as follows:

[0016] 1 Experimental materials

[0017] The International Standard Strain of Mycoplasma pneumoniae (ATCCFH15531) was purchased from the American Type Culture Collection.

[0018] Platycodon grandiflorum total saponins, laboratory extraction, the total saponin content of...

specific Embodiment approach 2

[0088] Specific embodiment two: the difference between this embodiment and specific embodiment one is that Platycodon grandiflorum total saponins are treated and prevented by oral administration, mucosal administration, respiratory tract administration or injection administration; wherein the treatment and prevention The subjects of the drug are humans and animals with diseases caused by MP infection; the dose for adults is 1-20 mg / Kg body weight, and the dose for animals is 0.5-100 mg / Kg body weight. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0089] Specific embodiment three: the difference between this embodiment and specific embodiment one is that bellflower acids, polygalic acids, bellflower diacids and bellflower A lactone saponins belong to 12-ene-oleanolic acid type pentacyclic triterpenes Saponin, its aglycone chemical general formula is as follows:

[0090]

[0091] Others are the same as in the first embodiment.

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Abstract

The invention relates to application of a platycodon root total saponin to medicaments for treating and preventing mycoplasma pneumoniae infectious diseases, and relates to application of platycodon root total saponin to medicaments. The platycodon root total saponin is used as the active ingredient of the medicaments for treating and preventing the mycoplasma pneumoniae infectious diseases, and is a composition of one or more of saponins of platycogenic acid, polygalic acid, platycogenic acid and platycogenic acid A lactone. The platycodon root total saponin has the effect of resisting mycoplasma pneumoniae; in-vitro experiments indicate that a minimal inhibitory concentration (MIC) value of resisting mycoplasma pneumoniae (MP) is between 16 and 64 mu g / ml, and the minimal bactericidal concentration (MBC) is between 64 to 128 mu g / ml; and in-vivo experiments indicate that after 8 mg / Kg and 16 mg / Kg of platycodon root total saponins are subjected to intragastric administration on BALB / C mice subjected to MP injection by nasal dropping for 10 days, the pathological injury of lungs of the mice can be relieved obviously, and the immunologic function of organisms is regulated, so the platycodon root total saponin has a treatment effect on the MP infection.

Description

technical field [0001] The invention relates to the application of total platycodon saponins in medicine. Background technique [0002] Bellflower is the root of Platycodon grandiflorum (Jacq.) A.DC., a plant in the Campanulaceae family. It is a traditional Chinese medicine in my country with a long history of medicinal use and is widely used. Its taste is bitter, pungent, and neutral in nature. Mainly returns to lung meridian. It has the effects of clearing the lung, resolving phlegm, relieving the throat, and evacuating pus. It is mainly used clinically for the treatment of cough with excessive phlegm, chest tightness, hoarseness of the throat, pulmonary abscess and vomiting of pus. The modern research on Platycodon grandiflora began in the 1940s, and its main active ingredient is oleanolic acid-type pentacyclic triterpene saponins. Scholars at home and abroad have found that the total saponins of platycodon grandiflora have anti-oxidation, anti-inflammatory and analges...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/34A61P11/00A61P31/04
Inventor 王伟明张俊威姚琳许庆瑞高菲谭思思王昶
Owner 黑龙江省中医研究院
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