Novel anticoccidial agent adprin solution and preparation method thereof

An adefuroline and anticoccidial technology, which is applied in the field of veterinary drug preparations and its preparation, can solve the problems of insolubility in water and easy precipitation of adefuroline solution, and is suitable for large-scale industrial production. , good application and promotion prospects, improve the effect of curative effect

Active Publication Date: 2012-11-21
广东华农高科生物药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the above-mentioned deficiencies in the prior art, the present invention provides a kind of adfuroline preparation, which can be mixed with any proportion of water without precipitation, and the active ingredient is stable. This preparation solves the problem of adfuroline being insoluble in water and The disadvantage of adfuroline solution is easy to precipitate in water, which increases the curative effect of the drug, improves the bioavailability of the drug, and is easy to use

Method used

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  • Novel anticoccidial agent adprin solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh 4g of adefuroline, 20g of glacial acetic acid, 25g of N,N-dimethylformamide, 5g of Tween 80, 9g of citric acid, 32g of absolute ethanol, and 5g of deionized water, and set aside;

[0038] At room temperature, mix adfuroline, glacial acetic acid, citric acid, and Tween 80 evenly, add to N,N-dimethylformamide, and keep stirring until a clear and transparent liquid is formed, then add absolute ethanol and stir After uniformity, 5 g of deionized water was added to obtain the adfuroline preparation.

Embodiment 2

[0040] Weigh 5g of adefuroline, 65g of glacial acetic acid, 10g of ethanolamine, 10.0g of castor oil polyoxyethylene ether (EL-40), and 10g of deionized water, respectively, and set aside;

[0041] At room temperature, mix adfuroline, ethanolamine, and castor oil polyoxyethylene ether (EL-40) evenly, dissolve in glacial acetic acid, and keep stirring until a clear and transparent liquid is formed, then add deionized water and stir until Clear and transparent liquid, that is, the preparation of adfuroline.

Embodiment 3

[0043] Respectively weigh 8g of adfuroline, 30g of glacial acetic acid, 30g of N,N-dimethylformamide, 8g of polyoxyethylene hydrogenated castor oil, 10g of salicylic acid, and 14g of deionized water, and set aside;

[0044] At room temperature, mix adfuroline and polyoxyethylene hydrogenated castor oil evenly, add glacial acetic acid and N,N-dimethylformamide, and keep stirring until a clear and transparent liquid is formed, then add salicylic acid , stirring continuously, then adding deionized water, stirring continuously, until a clear and transparent liquid is formed, that is, the adfuroline preparation is prepared.

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PUM

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Abstract

The invention discloses an anticoccidial adprin preparation, which comprises the following components in percentage by weight: adprin 4-15%, surfactant 5-15%, solvent 55-90%, and deionized water 1-15%. The invention also discloses a preparation method of the anticoccidial adprin preparation. The anticoccidial adprin preparation disclosed by the invention can be mixed with water in any ratio without precipitation, is convenient to use, and reduces administration cost and improves bioavailability and curative effect. The anticoccidial adprin preparation has simple preparation method and good stability, is easy for storage, and has good prospect of application and generalization.

Description

technical field [0001] The invention relates to a veterinary drug preparation and a preparation method thereof, in particular to an adeffurin preparation for preventing and treating chicken coccidiosis and a preparation method thereof. Background technique [0002] One of the keys to the treatment of chicken coccidiosis today is severe drug resistance. Adfurfuryl is a new generation of chemically synthesized anticoccidial drugs. Its main structure is different from other anticoccidial drugs. cross resistance. Studies have confirmed that Adprin has broad-spectrum anticoccidial activity, and it is effective against various Eimeria in chickens, such as Eimeria tenella, Eimeria fragilis, and poisonous Eimeria. worm, Eimeria giant, Eimeria heap type, and Eimeria brucei all have strong inhibitory and killing effects, and have played a good control effect. It is a high-efficiency, broad-spectrum, Low toxicity anticoccidiostats. Adefurin exerts its anticoccidial effect mainly by ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/52A61K47/44A61K47/26A61P33/02
Inventor 武力李美娣陈宝妮冯宝仪
Owner 广东华农高科生物药业有限公司
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