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Use of motherwort in the preparation of medicines for preventing and treating ischemic stroke

A technology of ischemic stroke and leonurine, applied in the directions of drug combination, cardiovascular system diseases, etc., can solve the problems such as the protection effect of leonurine on cerebral ischemia has not been seen yet.

Inactive Publication Date: 2011-11-30
FUDAN UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no report about the protective effect of the motherwortine on cerebral ischemia

Method used

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  • Use of motherwort in the preparation of medicines for preventing and treating ischemic stroke
  • Use of motherwort in the preparation of medicines for preventing and treating ischemic stroke
  • Use of motherwort in the preparation of medicines for preventing and treating ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The cerebral ischemia model test of embodiment 1 leonurine

[0019] Adopt the mature cerebral ischemia model of craniotomy to block the middle cerebral artery in the field, use the method of intragastric administration, and use the method of TTC staining to detect the cerebral infarction area of ​​the experimental model. The experimental data are analyzed by one-way analysis of variance, p<0.05, The results showed that motherwort can significantly reduce the volume of cerebral infarction.

[0020] Table 1 uses the TTC staining method to detect the infarct size, and the results show that motherwort can significantly reduce the cerebral infarct volume.

[0021] Table 1

[0022]

[0023] MDA reflects the degree of lipid peroxidation damage, superoxide dismutase (SOD), glutathione peroxidase (GSH-px), play a vital role in the body's oxidation and antioxidant balance, The enzyme can scavenge superoxide anion free radicals and protect cells from damage. The experiment o...

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Abstract

The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the application of the specific monomer leonurine in the Chinese herbal medicine motherwort in the preparation of pharmaceutical compositions, especially the application in the preparation of medicines for preventing and treating ischemic stroke. The present invention studies the middle cerebral artery occlusion experimental model through craniotomy, and the results show that the motherurine can improve the activity of glutathione peroxidase and superoxide dismutase; reduce lipid peroxidation products The level of malondialdehyde can reduce the size of cerebral infarction; increase the expression of Bcl-2 and reduce the expression of Bax protein; reduce the degree of mitochondrial swelling and increase the level of membrane potential. The result proves that said motherwortine has obvious protective effect on ischemic brain tissue, and can be used to prepare medicines for preventing and treating ischemic apoplexy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the application of the specific monomer leonurine in the Chinese herbal medicine motherwort in the preparation of pharmaceutical compositions, especially the application in the preparation of pharmaceutical compositions for preventing and treating ischemic stroke. Background technique [0002] Stroke has been an important cause of death and disability in both developed and developing countries in recent decades. Among them, ischemic stroke accounts for 70%. Studies have shown that the increase in the production of reactive oxygen species (Reactive oxygen species, ROS) in the body exceeds the scavenging capacity of the endogenous antioxidant system, leading to oxidative stress, which can accelerate the aging of the human body, increase the incidence of tumors, and also cause cerebrovascular system The injury, aggravating the degree of brain tissue damage. The e...

Claims

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Application Information

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IPC IPC(8): A61K31/235A61P9/10
Inventor 朱依谆祁佳刘新华朱依纯
Owner FUDAN UNIV
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