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Decolorizing method for gentamicin sulfate production

A technology of gentamicin sulfate and gentamicin, applied in the field of medicine and chemical industry, can solve the problems of decolorization cost of polluted environment, high residence, large amount of activated carbon, etc., and achieve reduction of decolorization production cost, large economic and social benefits, The effect of reducing environmental pollution

Inactive Publication Date: 2011-11-16
南阳普康药业有限公司 +1
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Problems solved by technology

[0002] At present, in the process of refining and decolorizing the production of gentamicin sulfate, the amount of activated carbon is large, and every billion gentamicin needs to consume 1Kg of activated carbon, and the activated carbon is discarded after use, causing pollution and high cost of decolorization

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  • Decolorizing method for gentamicin sulfate production
  • Decolorizing method for gentamicin sulfate production
  • Decolorizing method for gentamicin sulfate production

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Embodiment Construction

[0024] Gentamicin sulfate production decolorization method of the present invention is to adopt cold filtration in conjunction with the method for the decolorization of activated carbon fiber adsorption tower in the production of gentamicin sulfate, and this method is that gentamicin salt solution is filtered out macromolecular protein through low temperature After mixing with macromolecular pigments, an active carbon fiber tower is used for heating and adsorption decolorization, and the decolorized gentamicin sulfate solution is spray-dried to obtain finished gentamicin sulfate.

[0025] For this reason, Gentamicin Sulfate of the present invention produces decolorization method, specifically comprises the following steps:

[0026] ①. Cool the gentamicin salt solution to 3℃~7℃, filter it with a filter with a pore size of 16~30um, the titer of the filtrate is 200000~300000u / ml, and the transmittance of the filtrate at 460nm is 10%~20% between;

[0027] ②. Press the above filtr...

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Abstract

The invention discloses a decolorizing method for gentamicin sulfate production. The decolorizing method comprises: filtering out macromolecular proteins and macromolecular pigments from a gentamicin salt conversion solution at a low temperature, heating and performing adsorption-decolorizing with an activated carbon fiber adsorption tower, and performing spray-drying on the decolorized gentamicin sulfate solution to obtain a finished product namely gentamicin sulfate. The decolorizing method disclosed in the invention can replace the original activated carbon decolorizing process, recycle the activated carbon fiber after regeneration, reduce the environmental pollution caused by waste activated carbon and lower decolorizing cost, and has great economic and social benefits.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a new decolorization method in the production process of gentamicin sulfate. Background technique [0002] At present, in the process of refining and decolorizing the production of gentamicin sulfate, a large amount of activated carbon is used. Every billion gentamicin needs to consume 1Kg of activated carbon, and the activated carbon is discarded after use, resulting in environmental pollution and high decolorization costs. Contents of the invention [0003] For above-mentioned situation, in order to overcome the defective of prior art, the object of the present invention is exactly to provide a kind of novel gentamicin sulfate production decolorization method, to reduce waste activated carbon pollution and production cost. [0004] Another object of the present invention is to provide a gentamicin sulfate decolorization device used in the d...

Claims

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Application Information

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IPC IPC(8): C07H15/236C07H1/06B01D15/08
Inventor 赵晴段永平王香红李静仁刘增会马丽娜张景林
Owner 南阳普康药业有限公司
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