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Liquid dressing containing chitosan derivative and preparation method thereof

A technology of chitosan derivatives and liquid dressings, which is applied in the field of medical devices to achieve the effects of easy use, high transparency, and promotion of wound healing

Inactive Publication Date: 2011-11-02
QINGDAO MINGYAOTANG MEDICAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the development of biological dressings is very rapid [Courtenay M.Choosing wound dressings[J].Nursing Times, 1998,94(9):46248.], none of the dressings can meet the requirements of ideal dressings at present, and various types of dressings Both have their insurmountable shortcomings

Method used

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  • Liquid dressing containing chitosan derivative and preparation method thereof
  • Liquid dressing containing chitosan derivative and preparation method thereof
  • Liquid dressing containing chitosan derivative and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Get each component by following weight percentage:

[0044] Based on 1000g of liquid dressing, carboxymethyl chitosan 1%, collagen powder 0.5%, glycerin 10%, triclosan 0.2%, azone 5%, and the rest is deionized water.

[0045] Preparation:

[0046] 1) Weigh 10 g of carboxymethyl chitosan, add it into 350 g of deionized water and stir until completely dissolved to form liquid A, and leave it in place;

[0047] 2) Weigh 5g of collagen powder, add it into 200g of deionized water and stir until completely dissolved to form liquid B, keep it;

[0048] 3) Weigh 50 g of azone and 2 g of triclosan in sequence, dissolve them in 100 g of glycerol successively, and mix them uniformly to form liquid C;

[0049] 4) Pour liquids B and C into liquid A in turn and mix evenly to form mixed liquid D, then add the remaining deionized water and stir well until they are evenly mixed;

[0050] 5) Filling.

Embodiment 2

[0052] Get each component by following weight percentage:

[0053] Based on 1000g of liquid dressing, carboxymethyl chitosan 2%, collagen powder 0.4%, glycerol 12%, triclosan 0.25%, azone 8%, and the rest is deionized water.

[0054] Preparation:

[0055] 1) Weigh 20g of carboxymethyl chitosan, add it into 350g of deionized water and stir until completely dissolved to form liquid A, and leave it in place;

[0056] 2) Weigh 4g of collagen powder, add it to 200g of deionized water and stir until completely dissolved to form liquid B, keep it;

[0057] 3) Weigh 80 g of azone and 2.5 g of triclosan in sequence, dissolve them in 120 g of glycerol successively, and mix them uniformly to form liquid C;

[0058] 4) Pour liquids B and C into liquid A in turn and mix evenly to form mixed liquid D, then add the remaining deionized water and stir well until they are evenly mixed;

[0059] 5) Filling.

Embodiment 3

[0061] Get each component by following weight percentage:

[0062] Based on 1000g of liquid dressing, carboxymethyl chitosan 4%, collagen powder 0.3%, glycerol 15%, triclosan 0.3%, azone 10%, and the rest is deionized water.

[0063] Preparation:

[0064] 1) Weigh 40g of carboxymethyl chitosan, add it into 350g of deionized water and stir until completely dissolved to form liquid A, and leave it in place;

[0065] 2) Weigh 3g of collagen powder, add it into 200g of deionized water and stir until completely dissolved to form liquid B, keep it;

[0066] 3) Weigh 100 g of azone and 3 g of triclosan successively, dissolve them in 150 g of glycerol and mix them uniformly to form liquid C;

[0067] 4) Pour liquids B and C into liquid A in turn and mix evenly to form mixed liquid D, then add the remaining deionized water and stir well until they are evenly mixed;

[0068] 5) Filling.

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Abstract

The invention relates to a liquid dressing containing a chitosan derivative, comprising the following components in percentage by weight: 1-5% of CMCS (carboxymethyl chitosan), 0.1-0.5% of collagen albumen powder, 10-15% of humectant, 0.2-2% of antibacterial agent, 2-10% of penetration enhancers and the balance of deionized water. The liquid dressing is obtained by mixing the components in sequence, stirring evenly and bulking. The liquid dressing has the advantage of good biocompatibility, good antimicrobial, antiphlogistic and hemostatic effects and high biological safety, and is convenient to use.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular, the invention relates to a liquid dressing containing chitosan derivatives. Background technique [0002] With the proposal of the theory of moist wound healing, various new dressings have emerged. According to incomplete statistics, there are more than 2,400 kinds of wound dressings currently on the market [Krasner DL, Rodeheaver G T, Sibbald R G, et al chronic wound care[M]. 4th ed Malvem, PA: HMP Communications, 2007: 249]. How to choose the safest, economical and effective dressing according to the patient's wound condition and economic affordability is a problem often faced by Chinese medical staff in clinical work. Scholars at home and abroad have done a lot of research on dressing selection and application, but there is no consensus yet. Referring to the clinical effect research and related guidelines of dressings at home and abroad, the characteristics and clinical applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44
CPCA61L26/00A61L15/28A61L2300/418A61L15/32A61L15/44A61L2300/802A61L26/0066A61L2300/404A61L26/0052A61P17/02C08L89/06C08L5/08
Inventor 李育强孙士学
Owner QINGDAO MINGYAOTANG MEDICAL TECH DEV
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