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A kind of extracting and refining method of ginkgolide

A technology of ginkgolide and refining method, which is applied in the chemical industry, can solve the problems of complicated steps and high process cost, and achieve the effects of simplified production process, good safety and high purity

Active Publication Date: 2014-10-01
晨光生物科技集团天津有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main impurity removal and purification methods of ginkgolide production technology are: leaching, column purification, extraction, and crystallization to prepare ginkgolide. The process cost is high and the steps are complicated.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for extracting and refining ginkgolides, comprising the following steps:

[0031] 1) Pulverization: the ginkgo root bark that has been removed from impurities and cleaned is mechanically pulverized, and the pulverization fineness is 30 mesh;

[0032] 2) Soaking: Add saturated aqueous solution of sodium acetate and soak the Ginkgo root bark crushed through step 1) at normal temperature, soak for 2 times, and the soaking time is 2 hours and 1 hour respectively, the quality of the saturated aqueous solution of sodium acetate and Ginkgo root bark Ratio is successively 4: 1, 3: 1, discard filtrate, obtain filter residue;

[0033] 3) Extraction: extract the filter residue with hot water, the number of extractions is 4 times, the temperature of the hot water is 60°C, and the extraction time is 4 hours, 3 hours, 2 hours, and 1 hour. The mass ratio of the root bark is 6:1, 5:1, 4:1, 4:1, filtered to obtain the extract;

[0034] 4) Concentration: Concentrating the extr...

Embodiment 2

[0040] A method for extracting and refining ginkgolides, comprising the following steps:

[0041] 1) Pulverization: the ginkgo root bark that has been removed from impurities and cleaned is mechanically pulverized, and the pulverization fineness is 40 mesh;

[0042] 2) Soaking: add a saturated aqueous solution of sodium acetate to soak the Ginkgo root bark crushed in step 1) at normal temperature, soak once for 3 hours, and the mass ratio of the saturated aqueous solution of sodium acetate to the root bark of Ginkgo is 4:1 , discard the filtrate to obtain the filter residue;

[0043] 3) Leaching: filter residue is extracted with hot water, the number of times of extraction is 3 times, the temperature of hot water is 50°C, and the extraction time is 4.5 hours, 3.5 hours, and 2 hours. The mass ratio is 7:1, 6:1, 5:1, filtered to obtain the extract;

[0044] 4) Concentration: Concentrating the extract to 1 / 10 of the volume of the extract to obtain a concentrate;

[0045] 5) Di...

Embodiment 3

[0050] A method for extracting and refining ginkgolides, comprising the following steps:

[0051] 1) Pulverization: the ginkgo root bark that has been removed from impurities and cleaned is mechanically pulverized, and the pulverization fineness is 50 mesh;

[0052] 2) Soaking: add saturated aqueous solution of sodium acetate and soak the Ginkgo root bark crushed in step 1) at normal temperature, soak once for 1 hour, and the mass ratio of the saturated aqueous solution of sodium acetate to Ginkgo root bark is 5:1 , discard the filtrate to obtain the filter residue;

[0053] 3) Extraction: extract the filter residue with hot water, the number of extractions is 5 times, the temperature of the hot water is 70°C, the extraction time is 4.5 hours, 3 hours, 2 hours, 1 hour, 1 hour, the heat The mass ratio of water to ginkgo root bark is 7:1, 6:1, 6:1, 5:1, 4:1, filtered to obtain the extract;

[0054] 4) Concentration: Concentrating the extract to 1 / 15 of the volume of the extrac...

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PUM

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Abstract

The invention discloses a method for extracting and refining ginkgolide. The method comprises the following steps of: 1) crushing impurity-removed ginkgo root skin which is washed cleanly until the granular size is 30 to 50 meshes; 2) adding saturated aqueous solution of sodium acetate to soak the crushed impurity-removed ginkgo root skin, filtering the soaking solution and discarding the filtrate to obtain filter residues; 3) lixiviating the filter residues by using hot water and filtering to obtain leaching liquid; 4) concentrating the leaching liquid to obtain concentrated liquid; 5) dissolving the concentrated liquid with aqueous solution of ethanol, stirring and filtering to obtain filtrate; 6) concentrating until the ethanol is recovered completely to obtain concentrated liquid; 7) performing extraction by using ethyl acetate; and 8) concentrating and drying to obtain the high-content ginkgolide product. By the method, the loss of the ginkgolide is small; the solvent is saved; macromolecular impurities are removed completely; energy consumption is low; safety is high; no pollution exists; the method is simple in operation and easy in control; and production cost is low.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and relates to a method for extracting and refining ginkgolides. Background technique [0002] Ginkgolides belong to terpenoids, composed of sesquiterpene lactones and diterpene lactones, and are an important class of active ingredients in Ginkgo biloba leaves. Ginkgolide has important and extensive pharmacological effects such as anti-shock, anti-allergy, and anti-inflammation, showing broad clinical application prospects. Ginkgolide is currently the most promising drug for clinical application among natural anti-platelet activating factor (PAF) receptor antagonists. PAF is one of the mediators of various diseases. Among them, ginkgolide B antagonizes the selectivity and The most active. Ginkgolide can inhibit platelet aggregation, reduce blood viscosity, improve the microcirculation of ischemic patients, reduce thrombosis; at the same time stabilize the cell membrane and reduce the p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22
Inventor 张卫军李娜杨洋田洪张立欣
Owner 晨光生物科技集团天津有限公司
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