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Application of chorispora bungeana or extract thereof in preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and alpine ion mustard, which is applied in the field of medicine to achieve the effect of low price, prevention or improvement of heart and brain injury

Inactive Publication Date: 2011-08-03
LANZHOU UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The harsh living environment has created the unique efficacy of Alpine Ion Mustard, but there are no reports on the preparation method of its extract and the research on its anti-cerebral ischemic effect (Ayitul Khan, Tan Dunyan, Li Zhijun, etc. Research on the relationship between structure and environment [J]. Journal of Xinjiang Agricultural University, 1998, 21(4): 273-277; Real-time quantitative analysis of stress resistance expression[J]. Chinese Journal of Biochemistry and Molecular Biology, 2008, 24(6): 549-555; Zhang Lijing. Cloning, expression and antioxidant function analysis of alpine mustardin gene CbFer [D]. Lanzhou: Lanzhou University, 2006)

Method used

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  • Application of chorispora bungeana or extract thereof in preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases
  • Application of chorispora bungeana or extract thereof in preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases
  • Application of chorispora bungeana or extract thereof in preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Alpine mustard extract

[0021] From July to August every year, the alpine mustard plants are collected from the sunny gravel slopes near the Tianshan Mountains at an altitude of 3700-4000m, and they are transported back to the laboratory together with the soil in a cardboard box, and kept moist by spraying water on the way. Take 80g fresh whole plant of Alpine Ionic Mustard, select it to remove impurities, crush it with a pulverizer, put it in a 1000ml round bottom flask, add water 4 times the weight of the medicinal material, soak it for about 1 hour, heat it and boil it, extract it three times, 1.5 hours each time, filter (with 80 mesh nylon cloth), the combined filtrates were centrifuged at 3000rpm for 10min, the supernatant was concentrated, and freeze-dried into a dry extract to obtain 1.7g of Alpine mustard water extract.

Embodiment 2

[0022] The preparation of embodiment 2 Alpine mustard extract

[0023] From July to August every year, the alpine mustard plants are collected from the sunny gravel slopes near the Tianshan Mountains at an altitude of 3700-4000m, and they are transported back to the laboratory together with the soil in a cardboard box, and kept moist by spraying water on the way. Take 80g of fresh alpine mustard whole plant, select it to remove impurities, dry it, crush it with a pulverizer, put it in a 1000ml round bottom flask, add 4 times the weight of the medicinal material, soak it in water for about 1 hour, decoct it, extract it three times, each time 1.5 h, filter (using 80 mesh nylon cloth), combine the filtrates, centrifuge at 3000rpm for 10min, take the supernatant to concentrate, and freeze-dry to obtain a dry extract to obtain 6.9g of Alpine mustard water extract.

Embodiment 3

[0024] The preparation of embodiment 3 Alpine mustard extract

[0025] From July to August every year, the alpine mustard plants are collected from the sunny gravel slopes near the Tianshan Mountains at an altitude of 3700-4000m, and they are transported back to the laboratory together with the soil in a cardboard box, and kept moist by spraying water on the way. Take 80g fresh whole plant of Alpine mustard, cleanly select and remove impurities, crush it with a pulverizer, put it in a 1000ml round bottom flask, add 60%-80% (v / v) ethanol 4 times the weight of the medicinal materials, soak for about 1h, and reflux for 3 Once, each time 1h, filter (with 80 mesh nylon cloth), combine filtrate, 3000rpm centrifuge 10min, get supernatant and concentrate, lyophilize into dry extract to obtain 1.9g alpine mustard ethanol extract.

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Abstract

The invention belongs to the technical field of medicines, and provides application of chorispora bungeana or an extract thereof in the preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases. The extract of the chorispora bungeana comprises a water extract and an alcohol extract of the chorispora bungean. Studies indicate that the chorispora bungeana orthe extract thereof has the obvious effects of resisting cerebral ischemia, cerebral anoxia, cerebral thrombosis and vascular dementia in human bodies, has small side effect and can be taken for a long term.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the preparation of the extract of the alpine ion mustard, and the application of the alpine ion mustard or its extract in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the most threatening diseases to humans in the world today, and their morbidity and mortality have surpassed cancer and ranked first in the world. According to the data released by the Ministry of Health of China in 2008, the total mortality rate of the Chinese population is the highest among cardiovascular and cerebrovascular diseases. The mortality rate of urban residents is 19.65% for heart disease and 19.62% for cerebrovascular disease. Among them, for cerebrovascular diseases characterized by "high morbidity, high disability rate, high mortality rate, high recurr...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P9/00A61P9/10A61P25/28A61P7/02
Inventor 孙雅煊安黎哲刘婷王东晖盛红梅张华向云
Owner LANZHOU UNIVERSITY
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