Extract for preventing and treating angina pectoris and coronary heart disease and preparation method and application thereof

A technology of extracts and extracts, which is applied in the field of extraction of compound salvia miltiorrhiza preparations for cardiovascular drugs, which can solve the problems of lack of means for quality control, refinement, and no monitoring of active ingredients in extracts, etc.

Inactive Publication Date: 2011-07-13
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In the prior art, there is no step of monitoring and refining the active ingredients of the extract, so that the existing compound salvia miltiorrhiza preparations lack means for quality control, and the content of active ingredients still needs to be improved

Method used

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  • Extract for preventing and treating angina pectoris and coronary heart disease and preparation method and application thereof
  • Extract for preventing and treating angina pectoris and coronary heart disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Formula: Salvia miltiorrhiza 82.87%, Panax notoginseng 16.21%, Borneol 0.92%.

[0099] Preparation:

[0100] Step 1: Boil Danshen and Panax notoginseng with 8 times the weight of water to extract twice, the first time is 2 hours, the second time is 1 hour, and the extracts are mixed.

[0101] Step 2: Concentrate the extract, add ethanol until the alcohol content of the liquid is 65%, let it stand for 24 hours, recover the ethanol from the supernatant, and concentrate at normal pressure to form an extract.

[0102] Step 3, the extract and borneol are used as the active ingredient of the medicine, the matrix is ​​a eutectic mixture of xylitol and starch, and the feeding ratio is: extract medicine: matrix=1:5.5, add borneol, liquid paraffin is the condensing agent, and the medicine The temperature is 90° C., the materialization time is 1.5 hours, the condensate temperature is 1° C., the drop distance is 7 cm, and the drop speed is 35 drops per minute to prepare drop pills...

Embodiment 2

[0104] Recipe: Salvia 20%, Panax notoginseng 79%, Borneol 1%.

[0105] Step 1: Extracting Danshen and Panax notoginseng with 2 times the weight of water, the number of extractions is 2 times, each extraction is 1 hour, and the extracts are mixed.

[0106] In step 2, the extract is concentrated, and ethanol is added until the alcohol content of the liquid is 60%, and left to stand for 12 hours. The ethanol is recovered from the supernatant, and concentrated into an extract.

[0107] Step 3, use step 2 extract and borneol together as pharmaceutical active ingredient, substrate is eutectic mixture of xylitol and starch, feed ratio is: extract medicine: substrate=1: 3, add borneol, liquid paraffin is condensing agent , the drug temperature is 85°C, the material time is 1 hour, the condensate temperature is -2°C, the drop distance is 5cm, and the drop rate is 30 drops per minute.

Embodiment 3

[0109] Formula: Salvia 97%, Panax notoginseng 2%, Borneol 1.0%.

[0110] In step 1, the salvia miltiorrhiza and notoginseng are extracted with 12 times the weight of water, the number of extractions is 2 times, each extraction is 1 hour, and the extracts are mixed.

[0111] In step 2, the extract is concentrated, ethanol is added until the alcohol content of the medicinal solution is 70%, and it is left to stand for 12 hours. The supernatant is recovered with ethanol, concentrated into an extract or dried.

[0112] Step 3, use step 2 extract and borneol together as the active ingredient of the medicine, the substrate is a eutectic mixture of xylitol and starch, and the feeding ratio is: extract medicine: substrate=1:7, add borneol, and liquid paraffin is the condensing agent , the drug temperature is 95°C, the time of chemical change is 2 hours, the temperature of the condensate is 4°C, the drop distance is 10cm, and the drop speed is 45 drops per minute.

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Abstract

The invention relates to an extract for preventing and treating angina pectoris and coronary heart disease and a preparation method and application thereof. The preparation method comprises the following steps of: 1, extracting medicinal materials of root of red-rooted salvia and notoginseng root to obtain extracting solution; 2, concentrating or not concentrating the extracting solution, and carrying out alcohol precipitation to obtain the extract; and 3, preparing a medicinal preparation by using the extract and borneol as active ingredients of a medicine.

Description

Technical field: [0001] The invention relates to an extraction method of compound salvia miltiorrhiza preparation for cardiovascular drugs, in particular to a refining method of the extract. Background technique: [0002] Compound Danshen preparation is composed of Danshen, Panax notoginseng, borneol, etc. It has the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain. Compound Danshen preparation has been used for a long time in clinical diseases with microcirculation disorders. It has a remarkable curative effect in the treatment of systemic diseases, digestive system diseases, renal system diseases, etc. Therefore, it is more and more widely used. In recent years, in addition to medical system diseases, it is also widely used in dermatology. [0003] The main aspects of the therapeutic effect of compound Danshen preparation are: coronary heart disease, angina pectoris and microcirculation [0004] Nail fold microcirculation i...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/10A61K31/045
Inventor 刘岩戚可人刘顺航徐波陈红丛德刚赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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