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Qingpeng emplastrum for reducing swelling and stopping pain and preparation method thereof

A plaster, swelling and pain-relieving technology, which is applied in the directions of non-central analgesics, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Promotion and inappropriate use of drug efficacy and other issues to achieve the effects of reducing drug dosage, improving bioavailability, and long duration of action

Active Publication Date: 2013-03-20
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to the records of "Four Medical Codes" and "Jingzhu Materia Medica", combined with long-term practical experience, Tibetan folk doctors use Oxytropis chinensis, subrhubarb, iron club hammer, myrobalan, mulberry, emblica, benzoin, broad tendon, The Tibetan medicine Qingpeng ointment produced from musk is trusted by the majority of patients for its remarkable therapeutic effect. However, the traditional Tibetan medicine Qingpeng ointment preparation process is to mix all the original medicinal materials with fine powder to make ointment. The process is complicated and requires batch production. The cycle is long and the production process is unstable; the sources of raw materials and excipients are unstable, which is not conducive to industrial production; some drugs have poor penetration ability and low bioavailability, and the curative effect cannot be fully guaranteed, so it is not suitable to exert the curative effect of the drug; in addition, the product is not suitable for storage and is inconvenient to carry; Due to various reasons, the curative effect and promotion of the product have been greatly affected.
[0007] At present, there are no literature and product reports about the plaster prepared by modifying the dosage form based on the prescription of the traditional Tibetan medicine Qingpeng ointment

Method used

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  • Qingpeng emplastrum for reducing swelling and stopping pain and preparation method thereof
  • Qingpeng emplastrum for reducing swelling and stopping pain and preparation method thereof
  • Qingpeng emplastrum for reducing swelling and stopping pain and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0114] According to the specific embodiment of the present invention, the preparation method of Qingpeng plaster of the present invention can comprise a kind of in following A, B and C method:

[0115] A method:

[0116] ① Grind musk into fine powder;

[0117] ②Sort Oxytropis chinensis, subrhubarb, iron rod hammer, pitted myrobalan, myrobalan, emblical, benzoin, and vine, and crush them into medicinal powder with a particle size of 0.1-150 μm;

[0118] ③ Fully mix the above-mentioned medicinal powder with the above-mentioned musk fine powder, water-soluble polymer, transdermal accelerator, humectant, cross-linking agent, pH regulator, antibacterial agent and water, stir evenly, apply, condense, and cover the lining film , cutting, and packing to get Qingpeng plaster of the present invention.

[0119] Method B:

[0120] ① Remove impurities from Oxytropis chinensis, subrhubarb, iron rod hammer, seed myrobalan, myrobalan myrobalan, emblica, benzoin, vine vine, clean and mix; ...

experiment example 1

[0267] Experimental example 1: Screening experiment of auxiliary materials of Qingpeng plaster of the present invention

[0268] 1. Skeleton adhesive screening

[0269] The Chinese Pharmacopoeia 2010 Edition, an appendix "Plasters", stipulates under the General Rules of Plaster Preparations that the dosage form "commonly used bases include natural rubber, thermoplastic rubber, rosin, rosin derivatives, vaseline, lanolin and zinc oxide. It can also be used Other suitable solvents and matrices".

[0270] During the research process of the preparation process, the two major types of bases for the production of plasters were analyzed emphatically, and their respective advantages and disadvantages were screened and compared. The results are shown in Table 1.

[0271] Table 1 Comparison screening table of advantages and disadvantages of coatings prepared from two different matrix materials

[0272]

[0273] 2. Screening experiment of skin penetration enhancer:

[0274] ① Selec...

experiment example 2

[0315] Experimental Example 2: Comparative Experimental Data of Qingpeng Paste Plaster of the Present Invention and Qingpeng Ointment

[0316] Experimental sample:

[0317] Traditional Qingpeng ointment: provided by Tibet Qizheng Tibetan Medicine Co., Ltd.;

[0318] Qingpeng Ointment 1: Preparation method: ① Purify Oxytropis 100g, Subrhubarb 50g, Iron Bar Hammer 75g, Nucleus myrobalan 100g, Fructus myrobalan 100g, Emlical emblica 100g, benzoin 35g, and vine vine 150g, crush them , mixed evenly, and set aside; ②Weigh 50% of the total weight of the above-mentioned mixed raw materials, use 2.13kg of water, decoct 3 times at 85°C, and decoct for 2 hours each time, collect the extract and volatile oil respectively; filter, Concentrating the extract to a concentrated solution with a relative density of 1.0 to 1.5; adding the volatile oil to the concentrated solution; ③ pulverizing the above-mentioned remaining mixed raw medicine into a 100 μm powder, and mixing it with the above-me...

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Abstract

The invention provides an emplastrum for reducing swelling and stopping pain and a preparation method thereof. The composition of the emplastrum comprises an active ingredient and matrix, wherein the active ingredient is prepared from the following material drugs in parts by weight: 80-120 parts of thinleaf crazyweed, 30-70 parts of medium-grade Chinese teasel root, 50-100 parts of aconitum pendulum busch, 80-120 parts of denucleated medicine terminalia fruit, 80-120 parts of fruit of belleric terminalia, 80-120 parts of emblic leafflower fruit, 20-50 parts of benzoin, 130-170 parts of treebine stem and 10-40 parts of musk, wherein the matrix comprises the following auxiliary material in parts by weight: 50-6000 parts of binding agent. Compared with the traditional Qingpeng ointment, the emplastrum has the advantages of better stability, longer acting time and the like.

Description

technical field [0001] The invention relates to a plaster and a preparation method thereof, in particular to a plaster for relieving pain and swelling and a preparation method thereof. Background technique [0002] Qingpeng Ointment is a classic Tibetan medicine prescription composed by Tibetan folk doctors based on the records of "Tibetan Medicine and Supplements" and "Four Medical Codes", combined with practical experience. The prescription is included in the 95th edition of "Drug Standards issued by the Ministry of Health" The first volume of medicine, 322 pages. The prescription of Qingpeng ointment is: [0003] Oxytropis falciparum 100g, rhubarb sub 50g, hammer 75g, myrobalan 100g, myrobalan 100g, emblical 100g, benzoin 35g, vine vine 150g, musk 25g. [0004] Preparation method: the above nine flavors, except musk, which are ground into fine powder, the rest are ground into fine powder, sieved, added musk fine powder, mixed well, mixed with 8-year-old child urine, lar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/00A61K36/714A61K36/59A61K36/47A61K36/185A61K35/55A61P29/00A61K47/06A61K47/10A61K47/34A61K47/42A61K47/44
Inventor 张国霞黄玉兰陈丽娟张樱山刘鸿雁
Owner TIBET QIZHENG TIBETAN MEDICINE
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