Glucosamine hydrochloride capsule preparation and preparation method thereof

Abstract

The invention discloses a glucosamine hydrochloride capsule preparation and a preparation method thereof. The glucosamine hydrochloride capsule preparation consists of a capsule shell and contents, wherein the contents are glucosamine hydrochloride and magnesium stearate; and the ratio of the using amount of the glucosamine hydrochloride to the using amount of the magnesium stearate is 100:0.5-2. Compared with products sold in the market, the contents of the capsules of the invention reduce the sorts of auxiliary materials, control the using amounts of the auxiliary materials, reduce the total amount of the auxiliary materials for absorption and metabolism after a patient takes the capsules, avoid the occurrence of uncertain hazards and lighten the burden of keeping a pleasant ecological environment in the patient. Compared with processes for performing tabletting to form large tablets, crushing the large tablets, adding the magnesium stearate for uniform mixing and filling the mixture to form the capsule products sold in the market, the preparation process for the capsule preparation remarkably reduces loss in the production process as the steps of performing tabletting to form large tablets and crushing the large tablets are saved, is favorable for industrial production and reduces the cost.

Description

technical field [0001] The invention relates to a capsule preparation and a preparation method thereof, in particular to a glucosamine hydrochloride capsule preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Osteoarthritis (OA) is a chronic joint disorder syndrome characterized by progressive damage to articular cartilage. According to epidemiological surveys, the incidence of OA in people over 65 years old is 60% for men and 70% for women. With the increase of the world's aging population, the incidence of OA is also showing an increasing trend year by year. [0003] Drugs for the treatment of OA can be divided into several categories: analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and slow-acting drugs. In recent decades, NSAIDs have been widely used for the rapid relief of OA symptoms. According to their mechanism of action, NSAIDs are useless to prevent the patholog...

AI Technical Summary

Problems solved by technology

Since the content of the capsule preparation is a mixture of the main drug glucosamine and various auxiliary materials such as microcrystalline cellulose, povidone, and talcum powder, after taking the medicine, the patient must absorb and metabolize the active ingredient glucosamine hydrochloride. Metabolizing various excipients such as microcrystalline cellulose, povidone, and talcum powder undoubtedly increases uncertain risk factors and creates a burden for patients to maintain a good ecological environment

In addition, in order to increase the fluidity of the contents, the process of compressing into large pieces and then crushing, then adding magnesium stearate to mix evenly, and filling capsules is used. The poor fluidity of the powder during the production process makes it difficult to fill capsules, it is difficult to control the filling volume, and it is wasted. Too large, not conducive to industrial production, high cost

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