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Traditional Chinese medicinal composition, traditional Chinese medicinal preparation, preparation methods and use thereof

A technology of traditional Chinese medicine preparations and compositions, which is applied in the field of traditional Chinese medicine compositions, can solve problems such as the decrease in the number of pancreatic beta cells, and achieve the effect of promoting the recovery of pancreatic beta cell function and delaying apoptosis

Active Publication Date: 2011-02-16
LIAONING AODA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A recent study showed that, whether obese or non-obese patients with type 2 diabetes, compared with non-diabetic patients with similar body mass index, the number of islet β cells was significantly reduced, and the incidence of islet cell apoptosis was also significantly higher than that of normal people. , while there was no significant difference in the process of islet regeneration and differentiation between the two groups

Method used

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  • Traditional Chinese medicinal composition, traditional Chinese medicinal preparation, preparation methods and use thereof
  • Traditional Chinese medicinal composition, traditional Chinese medicinal preparation, preparation methods and use thereof
  • Traditional Chinese medicinal composition, traditional Chinese medicinal preparation, preparation methods and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Astragalus 312g, Vinegar Corydalis 625g, Panax notoginseng 250g, Radix Paeoniae Rubra 375g, Salvia miltiorrhiza 312g, Ligusticum chuanxiong 312g, safflower 312g, sumac 250g, Millipeda 312g. The above nine flavors and Panax notoginseng are crushed into fine powder; Yanhusuo plus 70% ethanol is refluxed for three times, the first time is refluxed for 3 hours with 4 times the amount, the second time is 4 times the amount for 2 hours, and the third time is 2 times the amount for reflux For 1 hour, filter, combine the filtrates, recover ethanol, and concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35 (60°C); take red ginseng 6 times the amount of ethanol, reflux for 2 hours, filter, recover ethanol, and depressurize Concentrate to a thick paste with a relative density of 1.30-1.35 (60°C), add 6 times the amount of 50% ethanol to the dregs, reflux for 1.5 hours, filter, add 8 times the amount of water to the dregs, decoct for 2 hours, filte...

Embodiment 2

[0041]Astragalus 250g, Vinegar Corydalis 500g, Panax notoginseng 200g, Radix Paeoniae Rubra 300g, Salvia miltiorrhiza 250g, Ligusticum chuanxiong 250g, safflower 250g, Sappan wood 200g, Spatholobus 250g. The above nine flavors and Panax notoginseng are crushed into fine powder; Yanhusuo is added with 60% ethanol and refluxed for three times, for the first time add 4 times the amount and reflux for 3 hours, for the second time add 4 times the amount and reflux for 2 hours, and for the third time add 2 times the amount for reflux For 1 hour, filter, combine the filtrates, recover ethanol, and concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35 (60°C); take red ginseng 6 times the amount of ethanol, reflux for 2 hours, filter, recover ethanol, and depressurize Concentrate to a thick paste with a relative density of 1.30-1.35 (60°C), add 6 times the amount of 40% ethanol to the dregs, reflux for 1.5 hours, filter, add 8 times the amount of water...

Embodiment 3

[0043] Astragalus 343g, Vinegar Corydalis 687g, Panax notoginseng 275g, Radix Paeoniae Rubra 412g, Salvia miltiorrhiza 343g, Ligusticum chuanxiong 343g, safflower 343g, Sappan 275g, Spatholobus 343g. The above nine flavors and Panax notoginseng are crushed into fine powder; Yanhusuo is added with 80% ethanol and refluxed for three times. For the first time, add 4 times the amount and reflux for 3 hours. For the second time, add 4 times the amount and reflux for 2 hours. For the third time, add 4 times the amount and reflux for 2 hours. For 1 hour, filter, combine the filtrates, recover ethanol, and concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35 (60°C); take red ginseng 6 times the amount of ethanol, reflux for 2 hours, filter, recover ethanol, and depressurize Concentrate to a thick paste with a relative density of 1.30-1.35 (60°C), add 6 times the amount of 60% ethanol to the dregs, reflux for 1.5 hours, filter, add 8 times the amount ...

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Abstract

The invention relates to a traditional Chinese medicinal composition, a traditional Chinese medicinal preparation, preparation methods and use thereof and belongs to the technical field of traditional Chinese medicinal preparations. The traditional Chinese medicinal composition is prepared from the following raw materials: astragalus, vinegar-prepared corydalis tuber prepared, pseudo-ginseng root, red paeony root, Salvia miltiorrhiza Bunge, szechwan lovage rhizome, safflower, sappan wood and suberect spatholobus stem. The traditional Chinese medicinal preparation comprises active ingredients and a pharmaceutically acceptable carrier. The traditional Chinese medicinal composition and the traditional Chinese medicinal preparation have the functions of inhibiting or delaying islet beta-cell apoptosis and promoting the restoration of the functions of the islet beta-cells.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and an application. Background technique [0002] Diabetes mellitus (DM) is an important modern disease, which can cause chronic complications of multiple system organs, lead to dysfunction and failure, and become the main cause of disability and death. In the past, type 1 diabetes was considered to be an autoimmune disease caused by genetics and the environment. The mechanism is mainly based on cellular immunity, inflammatory response factors, and apoptosis induced by oxidative free radicals. Type 2 diabetes is a disease of insulin resistance, degeneration and failure of pancreatic beta cells due to heredity and environment. The possible common mechanism of type 1 and type 2 diabetes is that oxidative stress induces islet cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P3/10
Inventor 于世家潘霖吕锐李尧军郭振海赵长会冯会生潘英宏田桂芳
Owner LIAONING AODA PHARM CO LTD
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