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Medicament for treating cancer, preparation method thereof and application thereof to preparation of medicaments

A technology of drugs and anti-tumor drugs, applied in the field of drugs, can solve the problems of no anti-tumor activity of Meliaceae triterpenes and no anti-cancer drugs

Inactive Publication Date: 2011-02-16
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no Meliaceae triterpenoids have been found to have anti-tumor activity, and there are no reports of anti-cancer drugs made of them as active ingredients.

Method used

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  • Medicament for treating cancer, preparation method thereof and application thereof to preparation of medicaments
  • Medicament for treating cancer, preparation method thereof and application thereof to preparation of medicaments
  • Medicament for treating cancer, preparation method thereof and application thereof to preparation of medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of neem triterpene compound 1-3 with antitumor activity:

[0024] Preparation technology of the present invention can be briefly described as:

[0025] From the branches and leaves of the cultivated neem (Azadirachta indica A.) collected from Yunnan and other places, crushed and extracted 3-4 times with 95% methanol cold soaking, half a day or 1 day each time, the combined extracts were concentrated under reduced pressure to nothing. Methanol was evaporated to obtain extract. Dilute the extract with a certain amount of distilled water, extract 3-4 times with petroleum ether, recover the petroleum ether under reduced pressure, and obtain the petroleum ether extraction part; extract the remaining water layer with ethyl acetate 3-4 times, recover under reduced pressure Finally, an ethyl acetate extraction fraction enriched in triterpenoids was obtained. The ethyl acetate fraction was subjected to normal pressure silica gel column chromatography, el...

Embodiment 2

[0040] Tablets: Tablets are prepared according to methods known in the art, each containing the following ingredients:

[0041] Any one of compound 1-3 obtained in embodiment 1 50mg

[0042] Lactose 70mg

[0043] Magnesium Stearate 3mg

[0044] Polyvinylpyrrolidone 7mg

[0045] Total 130mg

[0046] The tablets may, if desired, be film-coated with hydroxypropylmethylcellulose, talc and coloring agents.

Embodiment 3

[0048] Tablet: compound 1 or 2 or 310 mg obtained in Example 1, lactose 180 mg, starch 55 mg, magnesium stearate 5 mg;

[0049] Preparation method: mix compound 1 or 2 or 3, lactose and starch, moisten evenly with water, sieve the wet mixture and dry it, then sieve it, add magnesium stearate, and press the mixture into tablets, each weighing 250mg , the compound content is 10 mg.

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Abstract

The invention discloses an anti-tumor medicament which contains effective treatment amount of azadirachta indica triterpenoid 1 or 2 or 3 and a pharmaceutically acceptable carrier, compounds 1 to 3, a preparation method of a medicament which contains the compounds 1 to 3, and the application of the compounds to the preparation of medicaments for preventing and treating tumour diseases. Pharmacological experiment results show that the compounds 1 to 3 have extremely high anti-tumor bioactivity and provide a new way for the comprehensive utilization of azadirachta indica plants and the development of medicaments for preventing and treating cancers.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an antitumor medicine with neem triterpene compound as an active ingredient, its preparation method and its application in the preparation of medicines for treating and preventing cancer. Background technique [0002] Azadirachta indica A. is an evergreen tree of the family Meliaceae, native to South Asia and Southeast Asia, and distributed in tropical regions of India, Myanmar and other countries. It is an evergreen tree. Neem Azadirachta indica A. is a plant of the family Meliaceae, native to South and Southeast Asia, and is an evergreen tree. Neem is distributed in arid regions such as India, Pakistan, Thailand and Myanmar abroad. In the 1920s, it was introduced to Africa and other places as a tree species to prevent desertification in arid areas. At the beginning of this century, some dry and hot valleys in Yunnan, Sichuan, and Hainan have successfully introdu...

Claims

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Application Information

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IPC IPC(8): A61P35/02A61P35/00A61K31/365A61K31/575C07D493/06C07J53/00A61K31/343
Inventor 邱明华陈进雄李艳
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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