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Compositions and methods of detecting tiabs

A cancer and sample technology, applied in the field of evaluating the physiological state of the subject, can solve problems such as differences in mRNA heterogeneity

Active Publication Date: 2011-02-09
特兰斯麦迪公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, differences in mRNA heterogeneity isolated from normal and cancer cells from the same patient cannot be explained by differences occurring at the genomic level

Method used

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  • Compositions and methods of detecting tiabs
  • Compositions and methods of detecting tiabs
  • Compositions and methods of detecting tiabs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0144] A-Materials and methods

[0145] plasma sample

[0146] Blood samples were drawn from normal human subjects (n=26) seen at the local Nancy University Hospital for the purpose of biological testing not related to cancer. Clinical records were reviewed by trained physicians who determined that the subjects were not acutely ill, were not suspected of having active cancer, allergies, or autoimmune disorders. The group included patients with cancer risk factors such as smoking and obesity, one control who had had uterine cancer surgically removed 10 years before the blood sample was taken, and one who was pregnant when the blood sample was taken. Patients with COPD (n=12) were called to the same department (n=6) or to the nuclear medicine department of the same hospital (n=6). All patients with COPD were free of exacerbating events at the time of blood sampling. Patients (n=46) with various forms of solid tumors were sampled at pretreatment PET-CT assessment of cancer s...

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PUM

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Abstract

The present invention relates to novel methods and products for assessing the physiological status of a subject. More particularly, the invention relates to methods of assessing the presence, risk or stage of a cancer in a subject by measuring the levels of antibodies against particular aberrant protein domains in a sample from the subject, or the presence or number of immune cells bearing TCR specific for such aberrant protein domains. The invention is also suitable to assess the responsiveness of a subject to a treatment, as well as to screen candidate drugs and design novel therapies. The invention may be used in any mammalian subject, particularly in human subjects.

Description

technical field [0001] The present invention relates to new methods and products for assessing the physiological state of a subject. More specifically, the present invention relates to the determination of the level of antibodies directed against a particular abnormal protein domain, or the presence or number of immune cells with a TCR specific for such abnormal protein domain, in a sample from a subject. A method of assessing the presence, risk or stage of cancer in a subject. The invention is also applicable to assessing a subject's responsiveness to treatment, as well as screening drug candidates and designing new therapies. The present invention may be used with any mammalian subject, especially with human subjects. Background technique [0002] Cancer is gradually becoming the leading cause of death in Western countries, and the strong therapeutic benefit, >90% of patients with long-term disease-free survival, is mainly obtained in individuals diagnosed early 1 . ...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/53
CPCG01N2333/7051G01N2800/56G01N33/57484G01N2800/52C07K16/32G01N33/53G01N33/574G01N33/68
Inventor 伯纳德·毕海因维尔日妮·欧希尔玛丽·布鲁利亚德
Owner 特兰斯麦迪公司
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