Multidimensional optical information sensor for analyzing physical properties of particles

Abstract

The invention relates to equipment for analyzing physical properties of various particles, in particular to a multidimensional optical information sensor for analyzing physical properties of particles. The sensor comprises a laser source, a first focusing lens group, a diaphragm, a double-bellmouth flow pipe, an optical trap, a two-dimensional composite focusing system consisting of a hollow ellipsoidal reflecting surface and a second focusing lens group along the vertical direction of incident light, a diaphragm, a photoelectric detector, a two-dimensional spectral focusing system consisting of a lens and a planar mirror along the forward direction of incident light, a diaphragm and a photoelectric detector. The sensor can integrally acquire the particle light scattering universal transient optical information and convert to electrical signal, and has the characteristics of comprehensive and rich optical information and low light noise, the optical information acquisition system is compact in structure, and the application of optical lenses is flexible, thereby realizing integrated collection of four-dimensional optical information and completely reflecting the physical properties of various particles.

Description

technical field [0001] The invention relates to an analysis device for various particle properties, in particular to a particle property analysis multi-dimensional optical information sensor. Background technique [0002] The detection technology of the physical characteristics of particles of any shape (especially biological cells) is a science and technology that crosses many technical fields. Particles of any shape mainly include dust particles, biological cells, and urine sediment particles, etc., and their characteristics are relatively complex, and the main characteristics include size distribution, shape distribution, nuclear structure, etc. The optical sensing method mainly uses the relationship between the intensity spatial distribution characteristics of light scattering and the physical characteristics of particles to detect the types of particles, and the key is the conversion of effective photoelectric signals. At present, there are some applications of patente...

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Problems solved by technology

At present, there are some applications of patented technologies for special particles. For example, patented technology 200710192385.6 (optical sensor for large-flow dust particle counters) designed a spherical reflective side light information sensing method for dust particles, but this information cannot be comprehensively analyzed. Reflect the physical characteristics of the particles, and the scattering source and the receiving point are not in the focus, so the loss of the signal is more; another example is the patented technology CN92215120.2 (a new type of optical probe for laser dust particle counters) that uses ellipsoidal reflection side light In the information sensing method, although the scattering source and the receiving point are at the focal point, the light scattering at a small side angle will interact with the particles again, resulting in complex scattering, which affects the accuracy of information; another example is the patented technology CN101498646A for the three classifications of white blood cells (Small-angle forward laser light scattering sensor), this technology uses diode arrays as photoelectric receivers, and cylindrical mirrors process the light beams to obtain light scattering information at small forward angles and high forward angles, but for side sensors that sensitively reflect the internal structure of cells The direction information is not collected, so the ability to accurately identify multiple types of cells is limited; there is also US patent technology 2004 / 0197232 / A1 (recognition device for human blood cells by backscattering), which uses optical fiber array sensing from forward and backward The acquisition of particle scattering information effectively improves the accuracy of cell identification, but the extraction of backscattering signals is more complicated, and the lateral polarization information closely related to the nucleus and molecular structure is not collected, so the identification of cell particles is not strong.

In addition, some companies at home and abroad, such as Abbott in the United States, Sysmex in Japan, and Mindray in China, have some patented technologies for the development and application of light scattering technology in white blood cell identification and detection instruments (such as: MDOS four-angle laser patent measurement technology; laser method, flow cytometry, five classifications, etc.), but they are mainly equipped with the application of technologies such as chemistry, electronics, and fluorescence, and the optical sensing method is single. The present invention is purely optical, and is aimed at practical An optimized and integrated patented technology of particle multi-dimensional optical information sensing with universal application significance that has been improved for the shortcomings of the application

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