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Medicinal composition for resisting myocardial ischemia and hypoxia

An anti-myocardial ischemia and composition technology, applied in the field of anti-myocardial ischemia and hypoxia-resistant pharmaceutical compositions, can solve the problem of few effective parts of traditional Chinese medicine compound, and achieve obvious hypoxia-resistant and anti-myocardial ischemia Blood action, reduce the effect of myocardial infarction

Inactive Publication Date: 2012-01-11
YANCHENG INST OF HEALTH SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Judging from the literature, current research on the pharmacological effects of active ingredients of traditional Chinese medicine on experimental myocardial ischemia and hypoxia resistance mostly uses the effective parts of single Chinese medicines, and seldom studies the effective parts of traditional Chinese medicine compounds.

Method used

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  • Medicinal composition for resisting myocardial ischemia and hypoxia
  • Medicinal composition for resisting myocardial ischemia and hypoxia
  • Medicinal composition for resisting myocardial ischemia and hypoxia

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Experimental program
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Effect test

Embodiment Construction

[0010] 1. Preparation of drug

[0011] 1.1 Preparation of chrysanthemum total flavonoids:

[0012] Take white chrysanthemum flowers produced in Jiangsu, crush them, add 10 times the weight of 70% ethanol to reflux and extract twice (6 times, 4 times), each time for 2 hours, combine the extracts, recover the solvent until the relative density is 1.2 liquid extracts, add water to dilute into Each milliliter is equivalent to 0.2g of crude drug. Filter, and the filtrate is ready for use (measured total flavonoid content is 15.07mg.mL-1). The pretreated D101 macroporous adsorption resin is wet-packed, and the column volume is 100mL (wet weight 66g, dry weight 18g), diameter-to-height ratio is 1:8, precisely pipette 400mL of upper column liquid onto the column, and control the flow rate at 6 mL / min. Then use 3 times the column volume of purified water and 1 times the column volume of 20% ethanol to elute the impurities, control the flow rate to 6 mL / min, then use 3 times the column...

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Abstract

The invention relates to a medicinal composition for resisting myocardial ischemia and hypoxia, which is prepared from chrysanthemum general flavones and amaranthaceae saponins according to a weight ratio of 1:1. The general flavone content of the chrysanthemum general flavones is more than or equal to 60 percent (which is measured by a UV method), luteolin-7-O-D-glucoside content is more than orequal to 0.3 percent (which is measured by a HPLC method), and the general flavone content of the amaranthaceae saponins is more than or equal to 70 percent (which is measured by the UV method). The medicinal composition can reduce the degree of myocardial infarction, and has the obvious effects of resisting the myocardial ischemia and prolonging the hypoxia resistant time of mice.

Description

technical field [0001] The invention relates to a pharmaceutical composition for resisting myocardial ischemia and hypoxia. Background technique [0002] Chrysanthemum is Chrysanthemummorifoliumat. ) Dry flower heads of Tzvel. There are more than 30 species of chrysanthemums in the world, and about 17 species in China, but the main one that is cultivated for medicinal purposes is chrysanthemum. Different medicinal varieties, such as Chuju, Haoju, Jiju, Huaiju, Hangju, Gongju, Qiju, Huangju and so on. Chrysanthemum is a commonly used traditional Chinese medicine, which has the functions of dispelling wind, clearing away heat, improving eyesight and detoxifying. It is clinically used to treat hypertension and coronary heart disease. The main active ingredients of chrysanthemum are volatile oil and flavonoids, and the content of total flavonoids in chrysanthemum is high. Pharmacological studies have shown that the crude extract of chrysanthemum has antibacterial, anti-infl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/352A61K36/28A61P9/10
Inventor 罗崇念蔡红星卞庆亚王树树秦红兵王宁熊存全
Owner YANCHENG INST OF HEALTH SCI
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