Composite material copper-containing intrauterine device with porous structure

Abstract

The invention discloses a composite material copper-containing intrauterine device (IUD) with a porous structure. The IUD comprises a polymer framework with a porous structure and metal particles dispersed therein. A porogenic agent in a composite material copper-containing IUD with a compact structure, which is prepared from a uniform mixture of metal particles, matrix polymer and the porogenic agent through injection molding or press injection, is extracted and removed, so the composite material copper-containing intrauterine device (IUD) with the porous structure is obtained. The compositematerial copper-containing IUD with the porous structure completely has the advantage of the composite material copper-containing IUD with the compact structure, namely greatly relieving side effectssuch as bleeding and pain brought by the traditional IUD with a bare copper structure, and also has a unique advantage of greatly improving the effective utilization rate of copper particles by introducing the porous structure and further effectively improving the service life of the composite material IUD under the condition of not changing the addition amount of the copper particles.

Description

technical field [0001] The invention belongs to the field of composite materials and intrauterine devices, and specifically relates to a copper-containing composite intrauterine device with a porous structure. The intrauterine device includes a polymer skeleton with a porous structure and metal particles distributed therein. It is a composite copper-containing intrauterine device with a porous structure prepared by loading a porogen and subsequent porogen extraction and removal during the preparation of a composite copper-containing IUD with a dense structure. . technical background [0002] China is a populous country. The huge population base and the annual increase of nearly 10 million seriously restrict China's economic development, social progress and sustainable development. Solving the population problem as a whole is a major and urgent strategic task that China must face in the primary stage of socialism. The basic national policy of controlling the excessive growt...

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Problems solved by technology

However, common clinical side effects such as bleeding and pain have always been an obstacle to the further promotion and application of copper-containing IUDs with excellent contraceptive effects and more than 90% of the IUD market share.

[0004] However, copper-containing IUDs with dense structural composites are not perfect

Our unpublished results show that about one-third of copper particles are converted into copper ions in the dense structure composite copper-containing IUD before its copper ion release rate can ensure the contraceptive effect (not less than 2.0 μg / day) , that is, the effective utilization rate of copper particles in the copper-containing IUD of dense structure composite materials is only about one-third, so the service life of this type of composite IUD is severely limited when the content of copper particles remains unchanged.

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