Paeoniflorin and glycyrrhetinic acid composition and preparation method and application thereof

Abstract

The invention provides a paeoniflorin and glycyrrhetinic acid composition and a preparation method and application thereof for treating rheumatoid arthritis and eczema. The composition comprises paeoniflorin and glycyrrhetinic acid in a weight part ratio of 1:0.25-10. The composition can be prepared into various pharmaceutical formulations such as tablets, capsules, pills and the like; and the composition and other active ingredients form amulti-ingredient medicinal composition for providing a medicament with convenient administration and definite effect. The composition has good effect of treating rheumatoid arthritis and eczema.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition composed of paeoniflorin and glycyrrhetinic acid, a preparation method of the composition and its application in treating rheumatoid arthritis and eczema. Background technique [0002] Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic systemic, multiple, common autoimmune disease with a high disability rate that seriously endangers human health and affects the labor force. It is a chronic autoimmune joint disease with synovial inflammation as the main pathological manifestation. Its etiology and pathogenesis are extremely complicated, and at present, there is no definite and effective treatment drug. The etiology and pathogenesis of eczema are quite complex, involving various internal and external factors. It is a delayed type hypersensitivity (DTH) that occurs in the skin and involves immune imbalance in the body. Now mainly use H1 receptor antagonist...

AI Technical Summary

Problems solved by technology

[0005] The combination of peony and licorice has a long history. It is the classic ancient prescription Shaoyao Gancao Decoction in Zhang Zhongjing's "Treatise on Febrile Diseases. Debating the Syndrome of Taiyang Diseases and Treating It". It has been proved by long-term clinical practice that Shaoyao Gancao Decoction can relieve acute pain and treat various pains. However, at the same time, there are shortcomings such as unclear material basis of medicinal effect and difficult to determine the mechanism of action. The chemical composition of traditional Chinese medicine is the material basis for the exertion of medicinal effect, and it is also the premise of further in-depth research on traditional Chinese medicine.

Images