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Biphenylacylamine tetrazole compounds, synthetic method and application

A technology of methylbenzamide tetrazolium and compound, which is applied in the field of medicine, can solve the problem of low curative effect, and achieve the effect of novel chemical structure and easy-to-obtain raw materials

Inactive Publication Date: 2010-12-22
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology

The purpose of the present invention is to provide a [[(2-n-propyl-4-methyl-1H-benzene Imidazolium)-6-yl]formamide-1-yl]methylbenzamide tetrazole compound, synthesis method and use

Method used

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  • Biphenylacylamine tetrazole compounds, synthetic method and application
  • Biphenylacylamine tetrazole compounds, synthetic method and application
  • Biphenylacylamine tetrazole compounds, synthetic method and application

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Abstract

The invention relates to [[(2-n-propyl-4-methyl-1H-benzimidazole)-6-yl] formamide-1-yl] methyl biphenylacylamine tetrazole compounds, a synthetic method and application, and belongs to the technical field of medicaments. The structural formula of the compound is shown in the specification, wherein R1 is the [[(2-n-propyl-4-methyl-1H-benzimidazole)-6-yl] formamide-1-yl] methyl biphenylacylamine tetrazole compounds, and M is hydrogen, potassium or sodium. Experiments prove that the compounds have the excellent dual antagonist activity of an angiotensin II receptor and an endothelin receptor, and can be used for preparing medicaments for treating cardiovascular and cerebrovascular diseases.

Description

technical field The invention relates to the field of medical technology, and is a novel and simple [[(2-n-propyl-4-methyl-1H- Benzimidazole)-6-formamido-1-yl]methylbenzamide tetrazole compound and its synthesis method are used as medicine for treating cardiovascular and cerebrovascular diseases. Background technique Cardiovascular disease has a high incidence rate and many and serious complications, which seriously threaten human health. Non-peptide angiotensin AT1 receptor blockers (ARBs) are a new class of antihypertensive drugs that act on the renin-angiotensin system (RAS). Compared with angiotensin-converting enzyme inhibitors (ACEIs), The antihypertensive effect is more significant, the RAS is more selectively blocked, and the side effects are small, and it has been listed as one of the six major antihypertensive drugs. The renin-angiotensin system plays an important role in regulating blood pressure, body fluid balance and dielectric balance in the human body. It ...

Claims

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Application Information

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IPC IPC(8): C07D403/12A61K31/5377A61K31/496A61K31/454A61K31/4184A61P9/00
Inventor 周智明薛为哲章军何星
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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