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Compositions and methods for treating inflammation

Inflammation, technology for use in the field of compositions and methods for treating inflammation

Active Publication Date: 2014-04-16
REVALESIO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in contrast, mice lacking TSLPR did not develop asthma in response to inhaled antigen (Zhou et al., supra and Al-Shami et al., J. Exp. Med., 202:829-839, 2005)

Method used

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  • Compositions and methods for treating inflammation
  • Compositions and methods for treating inflammation
  • Compositions and methods for treating inflammation

Examples

Experimental program
Comparison scheme
Effect test

other Embodiment approach

[0120] Other embodiments provide a method of preparing an electrokinetically altered oxygenated aqueous fluid or solution, the method comprising using a mixing device for producing an output mixture by mixing a first material and a second material, the device comprising: a stator; having a rotor of an axis of rotation, the rotor being disposed within the stator and configured to rotate about the axis of rotation therein; a mixing chamber defined between the rotor and the stator, the mixing chamber having: an open first end, a first material Enter the mixing chamber through the open first end; and an open second end through which the output material exits the mixing chamber and the second material enters the mixing chamber through at least one of the rotor and the stator; the first chamber, which in communication with at least a majority of the open first end of the mixing chamber; and a second chamber in communication with the open second end of the mixing chamber.

[0121] Ot...

Embodiment approach

[0286] refer to Figure 12 , depicts mixing device 5000. Mixing device 5000 is an alternative embodiment of mixing device 100 . Components of the mixing device 5000 that correspond substantially similarly to components of the mixing device 100 are designated herein using the same reference numerals. Only components of the mixing device 5000 that are different from those of the mixing device 100 will be described.

[0287] The mixing device 5000 includes a housing 5500 for accommodating a rotor 600 and a stator 5700 . The stator 5700 may be non-rotatably connected to the housing 5500 by its first end portion 5712 and its second end portion 5714 . A chamber 5800 is defined between the housing 5500 and a portion 5820 of the stator 5700 flanked by a first end portion 5712 and a second end portion 5714 . Housing 5500 includes an inlet 5830 that provides access to chamber 5800 . The inlet 5830 may be oriented substantially perpendicular to the axis of rotation "α". However, th...

Embodiment 1

[0411] Dissolved Oxygen Stability

[0412] like Figure 30 Shown in , graphically illustrates dissolved oxygen levels in 500ml thin-walled plastic bottles and 1000ml glass bottles, each capped and stored at 65 degrees Fahrenheit.

[0413] As can be seen, when the plastic bottle was opened about 65 days after bottling, the dissolved oxygen level in the water was about 27.5 ppm. When the second bottle was opened about 95 days after bottling, the dissolved oxygen level was about 25 ppm. Likewise, for the glass bottles, the dissolved oxygen level was about 40 ppm on day 65 and about 41 ppm on day 95. Thus, the graph shows that when oxygen is diffused into the fluid using the described systems and methods, the dissolved oxygen levels in both plastic and glass bottles remain at relatively high rates at 65° Fahrenheit.

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Abstract

Provided are electrokinetically-generated fluids (e.g., gas-enriched electrokinetic fluids or solutions), and therapeutic compositions and methods for use in treating inflammation or at least one symptom of inflammation. The electrokinetically-generated fluids or therapeutic compositions and methods include electrokinetically-generated aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids (e.g., electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.

Description

field of invention [0001] Particular aspects relate generally to inflammation and modulating or modulating intracellular signal transduction, and more specifically relate to treatment by administering a therapeutic composition comprising at least one electrokinetic fluid (e.g., an electrokinetic oxygen-enriched fluid) of the invention. Compositions and methods for treating or preventing inflammation or at least one symptom of inflammation in a subject. Particular aspects relate to modulation of cellular membranes, membrane potentials, membrane proteins (e.g., At least one of membrane receptors, including but not limited to G protein-coupled receptors) and intercellular junctions (such as tight junctions, gap junctions, zona adherens, and desmasomes) to regulate intracellular signaling associated with inflammatory responses divert. Other aspects relate to combination therapy. [0002] Cross References to Related Applications [0003] This application claims U.S. Provisional...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K35/02
CPCG01N33/6872A61K31/137A61K45/06A61K31/58A61K31/7036C12N13/00A61K33/14A61K33/00A61P1/00A61P1/04A61P11/00A61P11/02A61P11/06A61P11/08A61P13/12A61P15/00A61P17/00A61P17/02A61P17/04A61P17/06A61P17/08A61P19/00A61P19/02A61P19/08A61P21/00A61P25/00A61P25/28A61P27/02A61P27/04A61P27/06A61P27/14A61P29/00A61P3/00A61P31/00A61P31/04A61P35/00A61P37/00A61P37/06A61P37/08A61P39/02A61P43/00A61P5/00A61P9/00A61P9/08A61P9/10A61P3/10A61K2300/00
Inventor 理查德·L·华森安东尼·B·伍德格雷戈里·J·阿咸宾
Owner REVALESIO CORP
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