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Unit discharge analysis method and system of neuron information

An analysis method and analysis system technology, applied in the field of neuron unit discharge analysis, can solve the problems of few data analysis indicators, poor versatility and scalability, etc., and achieve the effect of real-time processing

Active Publication Date: 2010-12-08
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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Problems solved by technology

For example, the literature: Effects of Electrical Stimulation of Primary Auditory Cortex on Neuronal Discharge of Lateral Inferior Colliculus in Salicylic Acid Tinnitus Model Rats (Acta Physiologica Sinica, April 25, 2009, 61(2): 121-126); The inhibitory effect of cortex on the spontaneous discharge of neurons in the ventral basal nucleus of the thalamus (Acta Physiologica Sinica, June 25, 2009, 61(3): 279-284), etc., which uses electrophysiological data, namely action potential analysis, mainly Using the microelectrode nuclei or the extracellular electrical activity of a single neuron or neuron group on the neural pathway, by analyzing the discharge behavior of neurons under specific stimulation conditions, to analyze how the nervous system encodes and perceives auditory information, according to its literature description , the realization of data analysis indicators is less, and a special data analysis system is required, and its versatility and scalability are not strong

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Embodiment Construction

[0012] The system is based on the multi-channel physiological recorder Powerlab as a bioelectrical signal acquisition system. The system realizes the online processing of digital signals through the DSP hardware module, including amplification, filtering, and neuron screening (spike sorting). The neuron discharge signal collected by the bioelectrical signal acquisition system is amplified by the preamplifier, and after analog-to-digital conversion, the filtered original waveform and the time stamps of the action potential after hardware classification are input through the high-speed data interface The unit discharge analysis system is stored in a special data storage area, and the graph acquisition unit Chart graphic acquisition module records neurons, providing users with a platform that combines a dedicated system (Tum-Key) and a customized system (Customer). A large amount of data analysis is realized by using Matlab programming language. The Matlab unit directly reads dat...

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Abstract

The invention discloses unit discharge analysis system and method, relating to the technical field of information processing. The method comprises the following steps of: selecting neuron peak potentials from superior segments through a peak selection unit, and determining the peak-peak interval of neurons; extracting the time interval of peak potentials of adjacent action potentials through the conversion of original data so as to carry out data conversion, respectively acquiring statistical values: frequency, complexity and superior segments according to different requirements, drawing a nerve rhythm feature multi-analysis diagram and judging the rhythm characteristics of the neutrons.

Description

technical field [0001] The invention relates to the technical field of biological information processing, in particular to a neuron unit discharge analysis method. Background technique [0002] It is one of the important contents of systems neuroscience to study the encoding and integration of neurons, and the neural mechanism that ultimately transforms into meaningful perception. At present, the research at this level mainly uses the extracellular electrical activity of a single neuron or a group of neurons on the microelectrode nuclei or neural pathways, and analyzes how the nervous system conducts "neuron neurons" by analyzing the discharge behavior of neurons under specific stimulation conditions. " encoding and perception. [0003] At present, frequency analysis is mostly used in the analysis of neuron information coding characteristics, that is, the number of discharges per unit time, and the analysis before and after the stimulation event equipped with the correspond...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00A61B5/04
Inventor 高洁隋建峰朱志茹伍亚民刘良明
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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