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Preparation method of Xiaojiean extract

A technology of extracts and extracts, which is applied in the field of preparation of extracts, can solve the problems of low transfer rate and achieve the effects of increasing extraction yield, improving the transfer rate of active ingredients, and improving drug efficacy

Active Publication Date: 2010-12-01
云南神威施普瑞药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking Xiaojie'an Capsules as an example, the above-mentioned current national drug standards stipulate that each capsule of Xiaojie'an Capsules shall contain no less than 0.03mg of berberine hydrochloride, while the actual content of berberine hydrochloride in each capsule of Xiaojie'an Capsules is generally 0.05-0.10mg Each Xiaojie'an capsule is equivalent to 1100mg of Gonglaomu medicinal material. Based on the Chinese Pharmacopoeia 2005 edition, the content of berberine hydrochloride in Gongluomu should not be less than 0.20%, and the transfer rate of berberine hydrochloride in the above method is only above 1.4%. , generally between 3.5 and 5.5%, compared with the general technical requirement that the active ingredient transfer rate should reach more than 50%, this transfer rate is quite low

Method used

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  • Preparation method of Xiaojiean extract
  • Preparation method of Xiaojiean extract
  • Preparation method of Xiaojiean extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Embodiment 1: (1) take the medicinal materials of Gongluomu, Sanchaku, Leonurus, Mildew Spatholobus, Smilax Smilax, and Forsythia, respectively crushing and cutting to make clean medicinal materials;

[0112] (2) Weigh 1100 parts of net medicinal materials Gongluomu, 750 parts of trigeminus, and 750 parts of motherwort, put them into a multifunctional extraction tank, add 8 times the amount (V / W) of 75% ethanol to reflux and extract twice, each time for 1.5 hours , filtered to obtain an extract, the extract was decompressed to recover ethanol and concentrated into a thick paste, dried, pulverized, mixed, and set aside;

[0113] (3) In addition, take 750 parts of pure medicinal materials Caulis Spatholobus, 900 parts of Smilax Smilax, and 750 parts of Forsythia, put them into a multifunctional extraction tank, add 7 times the amount (V / W) of 80% ethanol to reflux and extract twice, each After 2.5 hours, filter to obtain the extract, the extract is decompressed to recover...

Embodiment 2

[0115] Embodiment 2: 75% and 80% ethanol of the extraction solvent described in embodiment 1 are all replaced with 95% ethanol, and others are the same as in embodiment 1.

Embodiment 3

[0116] Embodiment 3: 75% and 80% ethanol of the extraction solvent described in embodiment 1 are all replaced with 50% ethanol, and others are the same as in embodiment 1.

[0117] Embodiment 3: The extraction solvent 75%, 80% ethanol described in embodiment 1 are all replaced with 70% ethanol, and others are the same as embodiment 1.

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Abstract

The invention relates to a preparation method of a Chinese complex prescription extract. The extract in the preparation method of the Xiaojiean extract is prepared from the following raw materials in parts by weight: 1100 parts of leatherleaf mahonia, 750 parts of evodia lepta, 750 parts of motherwort, 750 parts of spatholobus stem, 900 parts of glabrous greenbrier rhizome and 750 parts of forsythia suspense. The preparation method comprises the following steps of: (1) taking and making the leatherleaf mahonia, the evodia lepta, the motherwort, the spatholobus stem, the glabrous greenbrier rhizome and the forsythia suspense into net herbs; (2) weighting the leatherleaf mahonia, the evodia lepta and the motherwort, refluxing for extracting by adding 4-12 times (V / W) of 50-95% ethanol 2-4 times for 1-4 h every time, filtering to obtain an extracting solution, reducing the pressure of the extracting solution for recycling the ethanol, and condensing into thick paste, drying and crushing; (3) weighting the spatholobus, the glabrous greenbrier rhizome and the forsythia suspense, refluxing for extracting by adding 4-12 times (V / W) of 50-95% ethanol 2-4 times for 1-4 h every time, filtering to obtain an extracting solution, reducing the pressure of the extracting solution for recycling the ethanol, condensing into thick paste, drying and crushing; and (4) evenly mixing the products obtained in the step (2) and the step (3) to obtain the extract.

Description

technical field [0001] The invention relates to a preparation method of an extract of a traditional Chinese medicine compound preparation. Background technique [0002] Xiaojie'an (formerly known as Rupi'anxiao) is a traditional Chinese medicine compound preparation composed of six medicinal materials such as Gongluomu, Sanchaku, Leonurus, Mildew Spatholobus, Smilax Smilax, and Forsythia, including capsules, oral liquids and other dosage forms. Xiaojie'an The current national drug standards for capsules are recorded in the "National Compilation of Chinese Patent Medicine Standards" Landmark Upgrade National Standard Oral Oncology Pediatrics Subvolume (411-414 pages), standard number: WS-10433(ZD-0433)-2002, and the current national standards for Xiaojie'an Oral Liquid The drug standards are recorded in the "National Compilation of Chinese Patent Medicine Standards" Landmark National Standard Oral Oncology Pediatric Volume (415-418 pages), standard number: WS-10646(ZD-0646)-2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/90A61P15/14A61P15/00A61P35/00
Inventor 杨增明
Owner 云南神威施普瑞药业有限公司
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