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Drug composition containing small dosage of folic acid and aspirin and application thereof

A technology of aspirin and a composition is applied in the field of drugs for preventing or treating cardiovascular and cerebrovascular diseases, and can solve the problems of unsatisfactory prevention and treatment effect of cardiovascular and cerebrovascular diseases and the like

Inactive Publication Date: 2010-12-01
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The purpose of the present invention is to provide a new pharmaceutical composition for preventing or treating cardiovascular and cerebrovascular diseases, so as to solve the problem that the current prevention and treatment effect of cardiovascular and cerebrovascular diseases is not ideal

Method used

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  • Drug composition containing small dosage of folic acid and aspirin and application thereof
  • Drug composition containing small dosage of folic acid and aspirin and application thereof
  • Drug composition containing small dosage of folic acid and aspirin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1: the preparation of compound aspirin folic acid tablet (1000 pieces amount)

[0069] Recipe: Aspirin 50g

[0070] Folic acid 0.4g

[0071] starch g

[0072] Microcrystalline Cellulose 50g

[0073] Sodium carboxymethyl starch 20g

[0074] Low-substituted hydroxypropyl cellulose 20g

[0075] Proper amount of povidone ethanol solution

[0076] Magnesium Stearate 1%

[0077] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 50g of aspirin and 0.4g of folic acid and mix them uniformly according to the method of equal increase, add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the prescription amount, mix evenly according to the method of equal increase, and use 5% povidone K29 / 30-95% ethanol solution to make soft material, granulate with 20-mesh sieve, dry at 40°C for about 2 hours, g...

Embodiment 2～17

[0078] Embodiment 2~17: the preparation of the compound aspirin tablet of different content ratio (1000 pieces amount)

[0079] The preparation method of Examples 2-17 is the same as that of Example 1, and the granules obtained according to the formula shown in Table 1 are made into tablets.

[0080] Table 1 embodiment 2~17 tablet formula composition

[0081]

[0082] Continuation of Table 1 Embodiment 2~17 tablet formulations

[0083]

[0084]

Embodiment 18

[0085] Embodiment 18: Preparation of Compound Aspirin Folic Acid Capsules (1000 Capsules)

[0086] Recipe: Aspirin 50g

[0087] Folic acid 0.4g

[0088] Microcrystalline Cellulose 30g

[0089] Sodium carboxymethyl starch 20g

[0090] Proper amount of povidone ethanol solution

[0091] Micronized silica gel 1%

[0092] Magnesium Stearate 1%

[0093] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 50g of aspirin, 0.4g of folic acid, microcrystalline cellulose, and sodium carboxymethyl starch and mix them uniformly according to the method of equal increase, make a soft material with 5% povidone ethanol solution, granulate with a 30-mesh sieve, and granulate with a 18-mesh sieve , control the water content of the granules to be 2-3%; mix the prepared granules with glimepiride evenly, add micropowder silica gel and magnesium stearate, mix well, measure the content, and put them...

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Abstract

Cardiovascular and cerebrovascular diseases have high morbidity, mortality and disability rate and can bring heavy burdens for the society and families. Occurrence of dangerous cardiovascular and cerebrovascular events can be prevented through early prevention. The invention provides a drug composition containing one of small dosage of folic acid or methyltetrahydrofolic acid, medicinal content of aspirin and a medicinal carrier and application of the drug composition for preparing the drugs for preventing or treating the cardiovascular and cerebrovascular diseases. The invention belongs to the pharmaceutical field.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing small doses of folic acid, aspirin and a pharmaceutically acceptable carrier and the use of the pharmaceutical composition in preparing medicines for preventing or treating cardiovascular and cerebrovascular diseases. The present invention belongs to the field of pharmacy. Background technique [0002] Cardiovascular and cerebrovascular diseases have become the number one killer endangering people's health. According to statistics from the Ministry of Health, there are about 70 million patients with stroke and its sequelae in my country, 60 million patients with coronary heart disease, and 57% of middle-aged and elderly people over the age of 40 suffer from various degrees of cardiovascular and cerebrovascular diseases. According to statistics from the Ministry of Health in 2004, the mortality rate of cardiovascular and cerebrovascular diseases in my country's urban population was 200 / 10...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K31/519A61P9/00
Inventor 王文艳陈光亮徐希平
Owner 北京奥萨医药研究中心有限公司
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