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Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use

A nonylpyrimidine and diazepine technology, applied to new 1,4-diaza-bicyclo[3.2.2]nonylpyrimidine derivatives and their medical application fields, can solve the problem of no disclosed diazepine Second ring and other issues

Inactive Publication Date: 2010-10-06
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the diazabicyclo of the present invention has never been disclosed

Method used

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  • Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
  • Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
  • Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use

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Abstract

This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives of formula (I) and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Description

technical field The present invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonylpyrimidine derivatives and their use in the preparation of pharmaceutical compositions. The compounds of the present invention were found to be cholinergic ligands of nicotinic acetylcholine receptors and modulators of monoamine receptors and transporters. Due to their pharmacological properties, the compounds of the present invention can be used in the treatment of various diseases or disorders related to the cholinergic system of the central nervous system (CNS), peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, Endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms resulting from cessation of chemical substance abuse. Background technique The endogenous cholinergic neurotransmitter, acetylcholine, exerts its biological effects through two t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/08
CPCC07D471/08A61P1/04A61P1/12A61P11/06A61P13/12A61P15/04A61P15/10A61P17/00A61P25/00A61P25/04A61P25/06A61P25/08A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P25/30A61P3/04A61P43/00A61P9/12A61P3/10
Inventor D·佩特斯D·B·蒂默曼E·O·尼尔森G·M·欧尔森T·戴赫林J·K·克里斯坦森J·P·雷德罗伯J·D·米克尔森
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