Inorganic nano hybrid material of nuclear-shell-type fluorescent-labeled magnetic medicine and preparation method thereof
A fluorescent labeling and inorganic nanotechnology, which is applied in the direction of pharmaceutical formulations, drug combinations, inorganic non-active ingredients, etc., to achieve the effect of delaying drug release
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Embodiment 1
[0026] (1) Magnetic core Fe 3 o 4 Preparation of nanoparticles and their surface modification
[0027] Weigh 2.7093g FeCl 3 ·6H 2 O and 7.1832g CH3 COONa·3H 2 O was dissolved in 80mL of ethylene glycol, transferred to a 100mL reactor lined with polytetrafluoroethylene, crystallized at 200°C for 10 hours, cooled to room temperature naturally, and washed with ethanol and deionized water for 2- 3 times, after magnetic separation, vacuum drying at 60°C for 24 hours to obtain a black powder, denoted as Fe 3 o 4 .
[0028] Weigh 0.1g Fe 3 o 4 Dissolve in 100mL alcohol-water mixed solution, ultrasonically disperse and transfer to a four-necked flask, add 25wt% ammonia water until the pH value is equal to 10, add 4mL tetraethyl orthosilicate dropwise, stir at 40°C for 12 hours, wash with ethanol and Wash with deionized water for 3-5 times, and dry at 60°C for 24 hours to obtain gray powder silicon dioxide-modified ferric iron tetroxide, denoted as Fe 3 o 4 -SiO 2 .
[002...
Embodiment 2
[0036] (1) Magnetic core Fe 3 o 4 Preparation of nanoparticles and their surface modification
[0037] Weigh 2.801g FeCl 3 ·6H 2 O and 7.1963g CH 3 COONa·3H 2 O was dissolved in 80mL of ethylene glycol, transferred to a 100mL reactor lined with polytetrafluoroethylene, crystallized at 200°C for 10 hours, cooled to room temperature naturally, and washed with ethanol and deionized water for 2- 3 times, after magnetic separation, vacuum drying at 60°C for 24 hours to obtain a black powder, denoted as Fe 3 o 4 .
[0038] Weigh 0.1g Fe 3 o 4 Dissolve in 100mL alcohol-water mixed solution, ultrasonically disperse and transfer to a four-necked flask, add 25wt% ammonia water until the pH value is equal to 10, add 4mL tetraethyl orthosilicate dropwise, stir at 40°C for 12 hours, wash with ethanol and Wash with deionized water for 3-5 times, and dry at 60°C for 24 hours to obtain gray powder silicon dioxide-modified ferric iron tetroxide, denoted as Fe 3 o 4 -SiO 2 .
[00...
Embodiment 3
[0046] (1) Magnetic core Fe 3 o 4 Preparation of nanoparticles and their surface modification
[0047] Weigh 2.7893g FeCl 3 ·6H 2 O and 7.1923g CH 3 COONa·3H 2 O was dissolved in 80mL of ethylene glycol, transferred to a 100mL reactor lined with polytetrafluoroethylene, crystallized at 200°C for 10 hours, cooled to room temperature naturally, and washed with ethanol and deionized water for 2- 3 times, after magnetic separation, vacuum drying at 60°C for 24 hours to obtain a black powder, denoted as Fe 3 o 4 .
[0048] Weigh 0.1g Fe 3 o 4 Dissolve in 100mL alcohol-water mixed solution, ultrasonically disperse and transfer to a four-necked flask, add 25wt% ammonia water until the pH value is equal to 10, add 4mL tetraethyl orthosilicate dropwise, stir at 40°C for 12 hours, wash with ethanol and Wash with deionized water for 3-5 times, and dry at 60°C for 24 hours to obtain gray powder silicon dioxide-modified ferric iron tetroxide, denoted as Fe 3 o 4 -SiO 2 .
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