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Bone-strengthening food material

一种级分、乳蛋白质的技术，应用在不明原材料、食品制备、食品成分等方向，能够解决不能食品原材料使用等问题，达到抑制骨量减少、促进钙化的效果

Active Publication Date: 2010-09-22
SNOW BRAND MILK PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these substances themselves are drugs and cannot be used as food raw materials

Method used

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  • Bone-strengthening food material
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  • Bone-strengthening food material

Examples

Experimental program
Comparison scheme
Effect test

reference example 1

[0041] According to the following method (see Japanese Patent No. 3112637), a commercially available milk protein fraction whose bone strengthening effect was confirmed was prepared.

[0042] A column with a diameter of 10 cm filled with 0.5 liter of sulfonated Chitopearl (manufactured by Fuji Industries) as a cation exchange resin was sufficiently washed with deionized water. After making 50 liters of non-sterilized skim milk pass through the column with a flow rate of 100ml / min, the column is fully washed with deionized water, and 2.5 liters of 0.05M phosphate buffer solution (pH7.0) containing 0.95M sodium chloride is passed through the column so that Proteins adsorbed to the resin are eluted. Then, the eluate was desalted and concentrated by reverse osmosis (RO) membrane treatment, and then freeze-dried to obtain a powdery milk protein fraction. This operation was repeated twice to obtain 104 g of protein fractions. The isoelectric point of this protein fraction is 7.0-8...

Embodiment 1

[0044] A column with a diameter of 10 cm filled with 0.5 liter of sulfonated Chitopearl (manufactured by Fuji Industries) as a cation exchange resin was sufficiently washed with deionized water. After making 50 liters of non-sterilized skim milk pass through the column with a flow rate of 100ml / min, the column is fully washed with deionized water, and 2.5 liters of 0.05M phosphate buffer solution (pH7.0) containing 0.15M sodium chloride is passed through the column so that Proteins adsorbed to the resin are eluted. Then, the eluate was desalted and concentrated by reverse osmosis (RO) membrane treatment, and then freeze-dried to obtain a powdery milk protein fraction. This operation was performed 10 times, and 24.2 g of milk protein fractions were obtained. The molecular weight of this fraction is 6,000 to 150,000 Daltons, the isoelectric point is 6.0 to 11.0, and the basic amino acid is 12 to 14% of the constituent amino acids contained in this milk protein fraction. Moreov...

Embodiment 2

[0046] A column with a diameter of 10 cm filled with 0.5 liter of sulfonated Chitopearl (manufactured by Fuji Industries) as a cation exchange resin was sufficiently washed with deionized water. After making 50 liters of non-sterilized skim milk pass through the column with a flow rate of 100ml / min, the column was fully washed with 0.05M phosphate buffer (pH7.0) containing 0.05M sodium chloride to make the 0.05M solution containing 0.25M sodium chloride 2.5 liters of phosphate buffer (pH 7.0) was passed through the column to elute the protein adsorbed on the resin. Then, the eluate was desalted and concentrated by reverse osmosis (RO) membrane treatment, and then freeze-dried to obtain a powdery milk protein fraction. This operation was performed 5 times, and 12.8 g of milk protein fractions were obtained. The molecular weight of this fraction is 6,000 to 150,000 Daltons, the isoelectric point is 6.0 to 11.0, and the basic amino acid is 12 to 14% of the constituent amino acid...

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Abstract

Disclosed is a bone-strengthening agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) in the constitutional amino acid composition of the milk protein fraction, the basic amino acid content is 12 to 14 wt%, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.

Description

technical field [0001] The present invention relates to a milk protein fraction or a milk protein fraction degradation product having a bone strengthening effect. [0002] The milk protein fraction or the milk protein fraction decomposition product of the present invention has a bone strengthening effect, so it is used as a bone strengthening agent for the prevention or treatment of bone diseases, bone strengthening, etc., or as a bone strengthening agent for the prevention or treatment of bone diseases or bone It is very useful as an active ingredient for strengthening pharmaceuticals, food and beverages, and feed. Background technique [0003] In recent years, various bone diseases such as osteoporosis, bone fractures, and low back pain tend to increase along with aging. In bone tissue, osteogenesis and bone resorption are constantly going on, and a good balance between osteogenesis and bone resorption is maintained in youth, but as we age, the balance tends to bone resor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/305A23J1/20A23K1/16A61K38/00A61P19/08A23L33/17A23L33/18A61K38/02
CPCA23V2002/00A23C19/0917A23L2/66A23C19/082A23J1/20A21D2/263A23V2300/30A61K35/20A23L1/3056A23L33/19A61P19/00A61P19/08A61P19/10A23V2200/306A23V2250/5424
Inventor 芹泽笃森田如一上辻大辅小野爱子松山博昭日暮聪志
Owner SNOW BRAND MILK PROD CO LTD
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