Combination containing fotemustine

A composition and thymus technology, applied in the directions of medical preparations containing active ingredients, drug combinations, medical preparations without active ingredients, etc., can solve the problems of easily causing nausea and vomiting, obvious side effects, etc. The effect of reducing drug toxicity

Inactive Publication Date: 2010-08-18
YIPINHONG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both developed countries and developing countries have paid great attention to this disease. There are many drugs on the market for the treatment of this disease. For ex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: a kind of composition containing formustine,

[0011] formula:

[0012] The weight ratio of various ingredients is: thymosin 15%, formustine 15%, disodium hydrogen phosphate 2%, hydrochloric acid 3%, poloxamer 5%, sorbitol 10%, Tween 80 0.1%, mannitol 5%, 2% benzyl alcohol, plus 42.9% injection, the sum of the weight of various components is 100%.

[0013] Preparation: dissolve thymosin with formustine, hydrochloric acid, poloxamer, sorbitol, Tween 80, mannitol, and benzyl alcohol in proportion, and add an appropriate amount of sterile injection.

Embodiment 2

[0014] Embodiment 2: a kind of composition of formustine,

[0015] formula:

[0016] The weight ratio of various ingredients is: Thymosin 15%, Formustine 20%, Disodium Hydrogen Phosphate 2%, Hydrochloric Acid 3%, Poloxamer 5%, Sorbitol 10%, Tween 80 0.1%, Manna Alcohol 10%, benzyl alcohol 2%, plus injection 32.9%, the sum of the weight of various components is 100%.

[0017] Preparation: dissolve thymosin with formustine, hydrochloric acid, poloxamer, sorbitol, Tween 80, mannitol, and benzyl alcohol in proportion, and add an appropriate amount of sterile injection solution.

Embodiment 3

[0018] Embodiment 3: a kind of composition containing formustine,

[0019] formula:

[0020] The weight ratio of various ingredients is: Thymosin 20%, Formustine 20%, Disodium Hydrogen Phosphate 2%, Hydrochloric Acid 5%, Poloxamer 5%, Sorbitol 10%, Tween 80 0.2%, Manna Alcohol 10%, benzyl alcohol 2%, plus injection 25.8%, the sum of the weight of various components is 100%.

[0021] Preparation: dissolve thymosin with formustine, hydrochloric acid, poloxamer, sorbitol, Tween 80, mannitol, and benzyl alcohol in proportion, and add an appropriate amount of sterile injection solution.

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PUM

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Abstract

The invention relates to a combination containing fotemustine, which comprises an antitumor active ingredient, a thymus preparation and auxiliary materials, wherein the antitumor active ingredient is the fotemustine, the thymus preparation is an immunopotentiator, and the auxiliary materials comprise disodium hydrogen phosphate, hydrochloric acid, poloxamer, sorbitol, tween 80, mannitol and benzyl alcohol. By organically combining the immunopotentiator and the fotemustine which has favorable curative effect but larger toxicity, the invention effectively improves the drug effect, and greatly lowers the drug toxicity meanwhile.

Description

Technical field: [0001] The invention relates to an anticancer drug, in particular to an anticancer composition containing formustine. Background technique: [0002] Cancer is one of the diseases that threaten human survival and has the highest mortality rate in the world. Millions of patients die from such diseases every year. Both developed countries and developing countries have paid great attention to this disease. There are many drugs on the market for the treatment of this disease. For example, "Formustine" produced by Servier International Company of France has good curative effect, but it has obvious side effects. , such as prone to nausea and vomiting. Therefore, the research and development of antitumor drugs with stable drug properties, significant curative effect and low toxicity has become an urgent problem to be solved. Invention content: [0003] The invention aims at the deficiencies of the current technology, and provides an antitumor composition contain...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61K38/32A61K47/34A61P35/00A61K31/662A61K47/26
Inventor 李捍雄
Owner YIPINHONG PHARMACEUTICAL CO LTD
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