Organ preservation solution and preparation method thereof

Abstract

The invention provides an organ preservation solution and a preparation method thereof, which are characterized in that every 1000ml of organ preservation solution contains: 21 to 29mmol of potassium citrate, 6 to 10mmol of sodium dihydrogen phosphate, 30 to 45mmol of disodium hydrogen phosphate, 4 to 6mmol of magnesium sulfate, 1 to 3mmol of potassium chloride, 16 to 24g of dextran-40, 110 to 150mmol of mannitol, 4 to 6mmol of adenosine, 4 to 6mmol of acetylcysteine, 4 to 6mmol of sodium hydroxide, and the balance water for injection. The organ preservation solution is packaged by a dual-chamber bag, wherein the dextran-40 in the organ preservation solution is arranged in a first chamber and other components are arranged in a second chamber, and a weak welding separation belt is arranged between the adjacent chambers. The organ preservation solution has good stability and lower cost; and the organ preservation solution preparation method has simpler and more reasonable process, and is applicable to large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medical equipment and medical biology, and relates to a preservation solution of organ tissues or cells of a human body or an animal, specifically an organ preservation solution and a preparation method thereof. Background technique [0002] Human organ transplantation technology started in the early 20th century, after a hundred years of arduous exploration, it has become an effective and routine means to treat the end-stage of organ failure. In particular, organ transplantation technology in developed countries has become a new discipline in the medical field, and has achieved fruitful results and great progress. People's dependence on organ transplantation is increasing day by day. In the United States, every 16 minutes, one person joins the ranks of waiting for organ transplantation. In my country, there are 200,000 new uremia patients each year. According to the incomplete statistics of my country's...

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Problems solved by technology

However, due to the lack of a long-acting multi-organ preservation solution similar to or better than UW solution in my country, in a sense, it limits and hinders the development of other large organ transplantation work except kidney transplantation. Therefore, it is urgently needed at present. Develop a multi-organ preservation solution with good stability, low cost and good effect

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