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Application of cassia oil in preparation of Alpha 5-reductase inhibitor medicaments

A technology of reductase inhibitor and cinnamon oil, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., to achieve the effect of relieving obstruction symptoms, treating seborrheic alopecia, and clear drug effect

Inactive Publication Date: 2013-04-03
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cause of the disease has not been fully clarified, and now medical research believes that genetic factors and dihydrotestosterone are the main factors leading to male pattern hair loss

Method used

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  • Application of cassia oil in preparation of Alpha 5-reductase inhibitor medicaments
  • Application of cassia oil in preparation of Alpha 5-reductase inhibitor medicaments
  • Application of cassia oil in preparation of Alpha 5-reductase inhibitor medicaments

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Experimental program
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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 cinnamon oil of the present invention

[0022] After crushing the cinnamon, weigh 500g and place it in a 2000ml flask, add 3 times of water and soak for 60min, then add 15% NaCl solution as an auxiliary agent, and heat to keep the system in a boiling state. Move the steamed cinnamon oil-water emulsion into a centrifuge, and centrifuge at 4000r / min. Drain the water in the upper layer to obtain the volume of cinnamon oil. The yield of cinnamon volatile oil was 2.13%. Detected by HPLC, the cinnamaldehyde content is 83.56%. Its HPLC spectrum is as figure 1 shown.

[0023] Except adopting the cinnamon oil extraction method of the present invention to prepare, also can adopt supercritical fluid (CO 2 ) extraction method (He Cuiwei, orthogonal test optimal supercritical fluid CO of cinnamon aldehyde in cinnamon 2 ) extraction and GC-MS analysis, Journal of Guangxi College of Traditional Chinese Medicine, 2007, Volume 10, No. 1), steam dist...

Embodiment 3

[0052] Embodiment 3 Cinnamon oil of the present invention treats the clinical observation of seborrheic alopecia and its determination of serum dihydrotestosterone

[0053] 1. Case selection Inclusion criteria: 20-45 years old seborrheic alopecia patients, Norwood / Hamilton grade III-V, all have parietal alopecia. Exclusion criteria: patients with hypertension (blood pressure over 140 / 90mmHg for 3 consecutive time points) or patients with a history of heart, liver, kidney, endocrine, and psychological diseases; patients with seborrheic dermatitis, psoriasis or scalp infection ;Accept the drugs in this study, hair growth agents and drugs that may interfere with hair growth within the first 6 months (antihypertensive drugs, systemic use of corticosteroids, cytotoxic agents, antiepileptic drugs, bronchial and vasodilatory drugs) of patients.

[0054] 2. General situation

[0055] The 61 patients were randomly divided into two groups according to the treatment sequence. There we...

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Abstract

The invention provides an application of cassia oil in the preparation of Alpha 5-reductase inhibitor medicaments. The invention also provides a medicament composition which plays an Alpha 5-reductase inhibiting role. The cassia oil is used for an Alpha 5-reductase inhibitor, has definite medicine effect and strong controllability and provides a novel selection for clinic application.

Description

technical field [0001] The invention provides a new application of cinnamon oil, in particular, the application in the preparation of 5α-reductase inhibitor drugs. Background technique [0002] 5α-reductase inhibitors are an important class of drugs for the treatment of benign prostatic hyperplasia, male pattern baldness, and female hirsutism. 5α-reductase inhibitors are new drugs for the treatment of benign prostatic hyperplasia that have been marketed in recent years. 5α-reductase is widely present in the prostate and other tissues and organs. It is a catalytic enzyme that converts testosterone into dihydrotestosterone, and testosterone and dihydrotestosterone have different effects. 5α-reductase inhibitors can prevent testosterone from being converted into Dihydrotestosterone, thereby inhibiting the hyperplasia of the prostate gland. At present, such drugs mainly include finasteride and apretide. In recent years, small doses of 5α-reductase inhibitors have also been us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/54A61P13/08A61P17/14A61P17/08A61K129/00
Inventor 马松涛刘冬恋廖昌军
Owner CHENGDU MEDICAL COLLEGE
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