Preparation and application of total flavone extracted from plants, as well as pharmaceutical preparations thereof

A technology for total flavonoids and extracts, which is applied in the field of extracting total flavonoids and the preparation of pharmaceutical preparations thereof, can solve problems such as failure of western medicine treatment and inability to fundamentally solve problems and the like

Inactive Publication Date: 2010-06-23
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the development of pharmaceutical preparations using the total flavonoids of marshmallow flowers as raw materials is used to treat diabetes, especially for type 2 diabetes. Although western medicine emerges in an endless stream, it cannot fundamentally solve the problem, and western medicine treatment has certain side effects and "treatment failure". Taking full advantage of the relatively small side effects of traditional Chinese medicine and the advantages that patients can take it for a long time will have broad application prospects

Method used

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  • Preparation and application of total flavone extracted from plants, as well as pharmaceutical preparations thereof
  • Preparation and application of total flavone extracted from plants, as well as pharmaceutical preparations thereof
  • Preparation and application of total flavone extracted from plants, as well as pharmaceutical preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 The preparation of total flavonoids extract from hollyhock flower

[0017] Add an appropriate amount of 80% ethanol to the hollyhock flower, extract once, extract for 2 hours, combine the extracts, filter, concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 at 60°C, add an appropriate amount of water to sink for 24 hours, and filter with suction. Concentrate to the corresponding volume, pass through a macroporous adsorption resin column, use alcohol-water gradient elution, water elution 3 column volumes, 10% and 30% ethanol each elution 3 column volumes, 70% ethanol elution 1 column volume . The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract of the marshmallow flower, and the total flavonoid content is 65%.

Embodiment 2

[0018] Example 2 The preparation of the total flavonoid extract tablet of hollyhock flower

[0019] Take 150 g of total flavonoids extract from hollyhock flowers, 50 g of starch, and 45 g of microcrystalline cellulose, mix well, wet granulate with ethanol, and pass through a 20-mesh sieve. Add 5 g of magnesium stearate, mix well, and compress into 1000 tablets with a tablet weight of 0.25 g / tablet, each containing 150 mg of total flavonoids extract from hollyhock flowers. Usage: 2 tablets each time, three times a day.

Embodiment 3

[0020] Example 3 The preparation of total flavonoid extract capsules of marshmallow flowers

[0021] Take 150g of total flavonoids extract from hollyhock flowers, 150g of starch, and 50g of magnesium stearate, pass through an 80-mesh sieve, mix well, dry granulate, and fill 1000 capsules, each containing 150mg of total flavonoids extract from hollyhock flowers. Usage: 2 capsules each time, three times a day.

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Abstract

The invention discloses preparation and application of total flavone extracted from plants, as well as pharmaceutical preparations thereof. The invention is characterized in that total flavone extract of which the content is over 50 percent is extracted, separated and prepared from abelmoschus manihot, and then is mixed with pharmaceutical excipients and is prepared into a pharmaceutically acceptable solid preparation, and pharmacological experiment shows that the total flavone pharmaceutical preparations have hypoglycemic effect and can be applied to the treatment of diabetes.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to the preparation and application of total flavonoids extracted from plants and pharmaceutical preparations thereof. Background technique [0002] Hollyhock flower is the dry corolla (with stamens and style) of Abelmoschus manihot (L.) Medic., a plant of Malvaceae. 2002 edition. It has the effects of clearing dampness and heat, reducing inflammation and detoxification. It is a traditional medicinal plant in my country. The history of its use as medicine can be traced back to 1500 years ago in "The Back of the Elbow" written by Ge Hong in the Jin Dynasty. Gonorrhea, carbuncle, swollen toxin, and burns caused by soup and fire.” There are many applications among the people to treat furuncles, mumps, urinary tract infections, lung-heat coughs, and burns. In recent years, with the gradual deepening of research on its active ingredients and phar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/08A61K9/14A61K9/16A61K9/20A61K9/48A61P3/10A61K133/00
Inventor 张玲凌沛学尚立霞曲延伟吴永霞
Owner 凌沛学
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