Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof

A technology of antioxidant activity and extraction method, which is applied in the field of compounds with antioxidant activity and their extraction, can solve the problems of no report on the basis of active substances and no report on systematic research, and achieves the effect of simple extraction and separation process and free radical scavenging.

Inactive Publication Date: 2012-03-21
TIANJIN TIANSHI BIOLOGICAL DEV
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Problems solved by technology

[0004] Cotton ginseng has long been recorded in the famous Tibetan medicine "Jingzhu Materia Medica". At present, only Chengdu Institute of Biology, Chinese Academy of Sciences has divided 28-epi-cyasterone, Eriophytonoide, Cyasterone, ajuforrestinsA and B, 20- hydroxyecdysone, polypodinB, ajugalactone, 8-O-acetylharpagid, apigenin, -sitosterol daucosterol, and N-[2-hydroxy-(nonadecanoyl-tricosanoyl)]-4-hydroxytrans-8-sphingenine and other compounds, while its fat-soluble part and Systematic research on water-soluble parts has not been reported, and at the same time, research on the basis of its active substances has not been reported at home and abroad

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  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof
  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof
  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof

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Embodiment Construction

[0017] The following drawings and preferred embodiments detail the specific implementation and features provided according to the present invention as follows:

[0018] The chemical structural formula of the compound with antioxidant activity obtained in the present invention is:

[0019]

[0020] The compound is a colorless crystal, determined by ESI-MS m / z: 403[M+Na] + , 425[M+HCOO - ] - , Its molecular weight is 380, combined 1 H-NMR(CD 3 OD) and 13 C-NMR(CD 3 OD) data, confirm its molecular formula is C 16 H 28 O 10 , The degree of unsaturation is 3;

[0021] 1 H-NMR spectrum δ 4.69 (1H, d, J = 7.8 Hz) and 13 C-NMR spectrum δ99.6 is the characteristic signal of the anomeric proton and anomeric carbon of sugar, 13 C-NMR spectrum δ63.3 is the 6-CH of sugar 2 Signal, combined 1 H-NMR spectrum δ 3.87 (1H, dd, J=11.5, 1.7 Hz) and δ 3.64 (1H, dd, J=11.5, 5.5 Hz), indicating a β-glucose group; 13 The C-NMR spectrum shows that there are 16 signals, except for the 6 carbons of glucose, the...

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Abstract

The invention relates to a compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and an extracting method thereof. The compound is identified as new iridoid through modern spectral analysis, wherein the molecular weight is 380, and the molecular formula is C16H28O10. The extracting method comprises the following steps of: pulverizing whole eriophyton wallichii; extracting with ethanol; sequentially extracting by using petroleum ether, ethylacetate and water saturated n-butanol; carrying out chromatography on the n-butanol part by macroporous absorption resin; and carrying out column chromatography on 10 percent of an elution part sequentially through silica gel, ODS-A and Sephadex LH-20 so as to obtain wallchiiside A. The new iridoid has simple preparation method, low cost and obvious activity and provides a new compound for developing medicaments having antioxidant effects.

Description

Technical field [0001] The invention relates to a method for extracting new compounds from Tibetan medicine Mian ginseng, in particular to a compound with antioxidant activity extracted from Tibetan medicine Mian ginseng and an extraction method thereof. Background technique [0002] Tibetan medicine is a unique medical and health care method formed by the Tibetan people in our country in the process of long-term struggle with the natural environment. It is a treasure of traditional medicine in the motherland. Tibet is a plateau environment with high cold, lack of oxygen, strong radiation, and pollution-free. Therefore, Tibetan medicine has the characteristics of long growth cycle, unique curative effect, and high accumulation of active substances. Although there are Tibetan medicine health products on the market, the varieties are relatively single, and the efficacy factors and their structure-effect dose-effect relationships are not clear. This is not conducive to the developme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P39/06A23L1/29A23L33/00
Inventor 范秋领赵明明
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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